# 2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 7. Analysis of the effect of 3,5-dialkyl substituent size and shape on binding to four different dihydrofolate reductase enzymes

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/2-4-diamino-5-benzylpyrimidines-as-antibacterial-agents-7-analysis-of-the-effect/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Barbara Roth,Barbara S. Rauckman,Robert Ferone,David P. Baccanari,J.N. Champness,Richard M. Hyde |
| Citations | 35 |
| DOI | 10.1021/jm00385a017 |
| Fields | Chemistry |
| Open Access | true |
| OA Status | green |
| OA URL | https://doi.org/10.7270/q28c9xh6 |
| OpenAlex ID | https://openalex.org/W1973438035 |
| PMID | 3100802 |
| Type | article |
| Year | 1987 |

## Paper authors

- [Richard M. Hyde](https://scholariq.org/researchers/richard-m-hyde/)

## Paper primary topic

- [Synthesis and Characterization of Heterocyclic Compounds](https://scholariq.org/topics/synthesis-and-characterization-of-heterocyclic-compounds/)

## Paper topics

- [Synthesis and Characterization of Heterocyclic Compounds](https://scholariq.org/topics/synthesis-and-characterization-of-heterocyclic-compounds/)
- [Synthesis and biological activity](https://scholariq.org/topics/synthesis-and-biological-activity/)
- [Synthesis and Biological Evaluation](https://scholariq.org/topics/synthesis-and-biological-evaluation/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.