# A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/a-biomarker-stratified-comparison-of-top-down-versus-accelerated-step-up/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Nurulamin M Noor,James Lee,Simon Bond,Francis Dowling,Biljana Brezina,Kamal Patel,Tariq Ahmad,Paul Banim,James Berrill,Rachel Cooney,Juan De La Revilla Negro,Shanika de Silva,Shahida Din,Dharmaraj Durai,J Gordon,Peter M. Irving,Matthew W. Johnson,Alexandra Kent,Klaartje Kok,Gordon W. Moran,Craig Mowat,Pritash Patel,C Probert,Tim Raine,Rebecca Saich,Abigail Seward,Dan Sharpstone,Melissa Smith,Sreedhar Subramanian,Sara Upponi,Alan A. Wiles,Horace R. Williams,Gijs R. van den Brink,Séverine Vermeire,Vipul Jairath,Geert D’Haens,Eoin McKinney,Paul Lyons,James O. Lindsay,Nicholas A. Kennedy,Kenneth G. C. Smith,Miles Parkes,Nurulamin M Noor,James Lee,Simon Bond,Francis Dowling,Biljana Brezina,Kamal Patel,Tariq Ahmad,Paul Banim,James Berrill,Rachel Cooney,Juan De La Revilla Negro,Shanika de Silva,Shahida Din,Dharmaraj Durai,J Gordon,Peter M. Irving,Matthew W. Johnson,Alexandra Kent,Klaartje Kok,Gordon W. Moran,Craig Mowat,Pritash Patel,C Probert,Tim Raine,Rebecca Saich,Abigail Seward,Dan Sharpstone,Melissa Smith,Sreedhar Subramanian,Sara Upponi,Alan A. Wiles,Horace R. Williams,Gijs van Den Brink,Séverine Vermeire,Vipul Jairath,Geert D’Haens,Eoin McKinney,Paul Lyons,James O. Lindsay,Nicholas A. Kennedy,Kenneth G. C. Smith,Miles Parkes,Clare Allcock,Suhaylah Bhatti,Jonathan Blackwell,Robert Boulton-Jones,Matthew Brookes,Rhys O. Butcher,Jeffrey Butterworth,Karlena Champion,Rakesh Chaudhary,Andy Cole,Lauranne Derikx,Anjan Dhar,Mary Flowerdew,Rishi Goel,Ailsa Hart,R Hughes |
| Citations | 290 |
| DOI | 10.1016/s2468-1253(24)00034-7 |
| Fields | Biochemistry, Genetics and Molecular Biology,Immunology and Microbiology,Medicine |
| Open Access | true |
| OA Status | hybrid |
| OA URL | http://www.thelancet.com/article/S2468125324000347/pdf |
| OpenAlex ID | https://openalex.org/W4392059660 |
| PMID | 38402895 |
| Type | article |
| Year | 2024 |

## Paper authors

- [Séverine Vermeire](https://scholariq.org/researchers/severine-vermeire/)
- [Biljana Brezina](https://scholariq.org/researchers/biljana-brezina/)
- [C Probert](https://scholariq.org/researchers/c-probert/)

## Paper journal

- [˜The œLancet. Gastroenterology & hepatology](https://scholariq.org/journals/the-lancet-gastroenterology-and-hepatology/)

## Paper primary topic

- [Inflammatory Bowel Disease](https://scholariq.org/topics/inflammatory-bowel-disease/)

## Paper topics

- [Inflammatory Bowel Disease](https://scholariq.org/topics/inflammatory-bowel-disease/)
- [Autoimmune and Inflammatory Disorders](https://scholariq.org/topics/autoimmune-and-inflammatory-disorders/)
- [Biosimilars and Bioanalytical Methods](https://scholariq.org/topics/biosimilars-and-bioanalytical-methods/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.