# A structure-guided optimization of pyrido\[2,3-d\]pyrimidin-7-ones as selective inhibitors of EGFRL858R/T790M mutant with improved pharmacokinetic properties

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/a-structure-guided-optimization-of-pyrido-2-3-d-pyrimidin-7-ones-as-selective/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Lei Yu,Minhao Huang,Tianfeng Xu,Linjiang Tong,Xiao-E Yan,Zhang Zhang,Yong Xu,Cai‐Hong Yun,Hua Xie,Ke Ding,Xiaoyun Lu |
| Citations | 45 |
| DOI | 10.1016/j.ejmech.2016.12.006 |
| Fields | Biochemistry, Genetics and Molecular Biology,Chemistry,Medicine |
| Open Access | true |
| OA Status | green |
| OA URL | https://doi.org/10.7270/q2f47rd5 |
| OpenAlex ID | https://openalex.org/W2559605537 |
| PMID | 28033579 |
| Type | article |
| Year | 2016 |

## Paper authors

- [Zhang Zhang](https://scholariq.org/researchers/zhang-zhang/)

## Paper primary topic

- [HER2/EGFR in Cancer Research](https://scholariq.org/topics/her2-egfr-in-cancer-research/)

## Paper topics

- [HER2/EGFR in Cancer Research](https://scholariq.org/topics/her2-egfr-in-cancer-research/)
- [Cancer therapeutics and mechanisms](https://scholariq.org/topics/cancer-therapeutics-and-mechanisms/)
- [Quinazolinone synthesis and applications](https://scholariq.org/topics/quinazolinone-synthesis-and-applications/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.