# BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/bet-bromodomain-protein-inhibition-reverses-chimeric-antigen-receptor-extinction/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Weimin Kong,Alexander J. Dimitri,Wang Wenliang,In-Young Jung,Christopher J. Ott,Maria Fasolino,Yan Wang,Irina Kulikovskaya,Minnal Gupta,Todd Yoder,Jamie E. DeNizio,J.K. Everett,Erik F. Williams,Jun Xu,John Scholler,Tyler J. Reich,Vijay Bhoj,Kathleen M. Haines,Marcela V. Maus,J. Joseph Melenhorst,Regina M. Young,Julie K. Jadlowsky,Katherine T. Marcucci,James E. Bradner,Bruce L. Levine,David L. Porter,Frederic D. Bushman,Rahul M. Kohli,Carl H. June,Megan M. Davis,Simon F. Lacey,Golnaz Vahedi,Joseph A. Fraietta |
| Citations | 97 |
| DOI | 10.1172/jci145459 |
| Fields | Biochemistry, Genetics and Molecular Biology,Immunology and Microbiology,Medicine |
| Open Access | true |
| OA Status | bronze |
| OA URL | http://www.jci.org/articles/view/145459/files/pdf |
| OpenAlex ID | https://openalex.org/W3194126059 |
| PMID | 34396987 |
| Type | article |
| Year | 2021 |

## Paper authors

- [David L. Porter](https://scholariq.org/researchers/david-l-porter/)

## Paper primary topic

- [CAR-T cell therapy research](https://scholariq.org/topics/car-t-cell-therapy-research/)

## Paper topics

- [CAR-T cell therapy research](https://scholariq.org/topics/car-t-cell-therapy-research/)
- [Protein Degradation and Inhibitors](https://scholariq.org/topics/protein-degradation-and-inhibitors/)
- [Immune Cell Function and Interaction](https://scholariq.org/topics/immune-cell-function-and-interaction/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.