# Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/cancer-stem-like-properties-and-gefitinib-resistance-are-dependent-on-purine/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Tatsunori Nishimura,Asuka Nakata,Xiaoxi Chen,Kurumi Nishi,Makiko Meguro‐Horike,Soichiro Sasaki,Kenji Kita,Shin‐ichi Horike,Kaori Saitoh,Keiko Kato,Kaori Igarashi,Takahiko Murayama,Susumu Kohno,Chiaki Takahashi,Naofumi Mukaida,Seiji Yano,Tomoyoshi Soga,Arinobu Tojo,Noriko Gotoh |
| Citations | 116 |
| DOI | 10.1038/s41388-018-0589-1 |
| Fields | Biochemistry, Genetics and Molecular Biology |
| Open Access | true |
| OA Status | hybrid |
| OA URL | https://www.nature.com/articles/s41388-018-0589-1.pdf |
| OpenAlex ID | https://openalex.org/W2903802773 |
| PMID | 30532069 |
| Type | article |
| Year | 2018 |

## Paper authors

- [Kaori Saitoh](https://scholariq.org/researchers/kaori-saitoh/)

## Paper primary topic

- [Cancer, Hypoxia, and Metabolism](https://scholariq.org/topics/cancer-hypoxia-and-metabolism/)

## Paper topics

- [Cancer, Hypoxia, and Metabolism](https://scholariq.org/topics/cancer-hypoxia-and-metabolism/)
- [Biochemical and Molecular Research](https://scholariq.org/topics/biochemical-and-molecular-research/)
- [Epigenetics and DNA Methylation](https://scholariq.org/topics/epigenetics-and-dna-methylation/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.