# Catechol Pyrazolinones as Trypanocidals: Fragment-Based Design, Synthesis, and Pharmacological Evaluation of Nanomolar Inhibitors of Trypanosomal Phosphodiesterase B1

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/catechol-pyrazolinones-as-trypanocidals-fragment-based-design-synthesis-and/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Kristina M. Orrling,Chimed Jansen,Xuan Lan Vu,Vreni Balmer,Patrick Bregy,Anitha Shanmugham,P. England,David Bailey,Paul Cos,Louis Maes,Emily R. Adams,Erika van den Bogaart,Eric Chatelain,Jean‐Robert Ioset,Andrea van de Stolpe,Stèphanie Zorg,Johan J. N. Veerman,Thomas Seebeck,Geert Jan Sterk,Iwan J. P. de Esch,Rob Leurs |
| Citations | 56 |
| DOI | 10.1021/jm301059b |
| Fields | Biochemistry, Genetics and Molecular Biology,Medicine |
| Open Access | true |
| OA Status | green |
| OA URL | https://doi.org/10.7270/q2sf2x96 |
| OpenAlex ID | https://openalex.org/W2072523970 |
| PMID | 22963052 |
| Type | article |
| Year | 2012 |

## Paper authors

- [Vreni Balmer](https://scholariq.org/researchers/vreni-balmer/)

## Paper primary topic

- [Trypanosoma species research and implications](https://scholariq.org/topics/trypanosoma-species-research-and-implications/)

## Paper topics

- [Trypanosoma species research and implications](https://scholariq.org/topics/trypanosoma-species-research-and-implications/)
- [Phosphodiesterase function and regulation](https://scholariq.org/topics/phosphodiesterase-function-and-regulation/)
- [Research on Leishmaniasis Studies](https://scholariq.org/topics/research-on-leishmaniasis-studies/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.