# Clinical Acquired Resistance to KRASG12C Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS–MAPK Reactivation

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/clinical-acquired-resistance-to-krasg12c-inhibition-through-a-novel-kras-switch/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Noritaka Tanaka,Jessica J. Lin,Chendi Li,Meagan B. Ryan,Junbing Zhang,Lesli A. Kiedrowski,Alexa Michel,Mohammed U. Syed,Katerina A. Fella,Mustafa Sakhi,Islam Baiev,Dejan Juric,Justin F. Gainor,Samuel J. Klempner,Jochen K. Lennerz,Giulia Siravegna,Liron Bar‐Peled,Aaron N. Hata,Rebecca S. Heist,Ryan B. Corcoran |
| Citations | 526 |
| DOI | 10.1158/2159-8290.cd-21-0365 |
| Fields | Biochemistry, Genetics and Molecular Biology |
| Open Access | true |
| OA Status | bronze |
| OA URL | https://cancerdiscovery.aacrjournals.org/content/candisc/11/8/1913.full.pdf |
| OpenAlex ID | https://openalex.org/W3142010099 |
| PMID | 33824136 |
| Type | article |
| Year | 2021 |

## Paper authors

- [Rebecca S. Heist](https://scholariq.org/researchers/rebecca-s-heist/)
- [Jochen K. Lennerz](https://scholariq.org/researchers/jochen-k-lennerz/)
- [Justin F. Gainor](https://scholariq.org/researchers/justin-f-gainor/)
- [Aaron N. Hata](https://scholariq.org/researchers/aaron-n-hata/)

## Paper journal

- [Cancer Discovery](https://scholariq.org/journals/cancer-discovery/)

## Paper primary topic

- [Cancer therapeutics and mechanisms](https://scholariq.org/topics/cancer-therapeutics-and-mechanisms/)

## Paper topics

- [Cancer therapeutics and mechanisms](https://scholariq.org/topics/cancer-therapeutics-and-mechanisms/)
- [Melanoma and MAPK Pathways](https://scholariq.org/topics/melanoma-and-mapk-pathways/)
- [DNA Repair Mechanisms](https://scholariq.org/topics/dna-repair-mechanisms/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.