# Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2<i>H</i>)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/discovery-of-2-6-5-chloro-2-methoxyphenyl-4-oxo-2-thioxo-3-4-dihydropyrimidin-1/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Roger B. Ruggeri,Leonard Buckbinder,Scott W. Bagley,Philip A. Carpino,Edward L. Conn,Matthew Dowling,Dilinie P. Fernando,Wenhua Jiao,Daniel W. Kung,Suvi T. M. Orr,Yingmei Qi,Benjamin N. Rocke,Aaron Smith,Joseph S. Warmus,Yan Zhang,Daniel M. Bowles,Daniel W. Widlicka,Heather Eng,Tim F. Ryder,Raman Sharma,Angela Wolford,Carlin V. Okerberg,Karen Walters,Tristan S. Maurer,Yanwei Zhang,Paul D. Bonin,Samantha N. Spath,Gang Xing,David Hepworth,Kay Ahn,Amit S. Kalgutkar |
| Citations | 58 |
| DOI | 10.1021/acs.jmedchem.5b00963 |
| Fields | Chemistry,Immunology and Microbiology,Pharmacology, Toxicology and Pharmaceutics |
| Open Access | true |
| OA Status | green |
| OA URL | https://doi.org/10.7270/q2sq926x |
| OpenAlex ID | https://openalex.org/W2290661108 |
| PMID | 26509551 |
| Type | article |
| Year | 2015 |

## Paper authors

- [Wenhua Jiao](https://scholariq.org/researchers/wenhua-jiao/)

## Paper primary topic

- [Neutrophil, Myeloperoxidase and Oxidative Mechanisms](https://scholariq.org/topics/neutrophil-myeloperoxidase-and-oxidative-mechanisms/)

## Paper topics

- [Neutrophil, Myeloperoxidase and Oxidative Mechanisms](https://scholariq.org/topics/neutrophil-myeloperoxidase-and-oxidative-mechanisms/)
- [Synthesis and Biological Evaluation](https://scholariq.org/topics/synthesis-and-biological-evaluation/)
- [Bioactive Compounds and Antitumor Agents](https://scholariq.org/topics/bioactive-compounds-and-antitumor-agents/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.