# Discovery of a 5<i>H</i>-Benzo\[4,5\]cyclohepta\[1,2-<i>b</i>\]pyridin-5-one (MK-2461) Inhibitor of c-Met Kinase for the Treatment of Cancer

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/discovery-of-a-5-i-h-i-benzo-4-5-cyclohepta-1-2-i-b-i-pyridin-5-one-mk-2461/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Jason D. Katz,James P. Jewell,David Guérin,Jongwon Lim,Christopher J. Dinsmore,Sujal V. Deshmukh,Bo‐Sheng Pan,C. Gary Marshall,Wei Lu,Michael D. Altman,William K. Dahlberg,Lenora J. Davis,Danielle Falcone,Ana E. Gabarda,Gaozhen Hang,Harold Hatch,Rachael Holmes,Kaiko Kunii,Kevin J. Lumb,Bart Lutterbach,Robert J. Mathvink,Naim Nazef,Sangita B. Patel,Xianlu Qu,John F. Reilly,Keith Rickert,Craig Rosenstein,S.M. Soisson,Kerrie B. Spencer,Alexander A. Szewczak,Deborah Walker,Wenxian Wang,Jonathan R. Young,Qinwen Zeng |
| Citations | 60 |
| DOI | 10.1021/jm200112k |
| Fields | Biochemistry, Genetics and Molecular Biology,Medicine |
| Open Access | true |
| OA Status | green |
| OA URL | https://doi.org/10.7270/q2x34zfz |
| OpenAlex ID | https://openalex.org/W2017608864 |
| PMID | 21608528 |
| Type | article |
| Year | 2011 |

## Paper authors

- [Wenxian Wang](https://scholariq.org/researchers/wenxian-wang/)

## Paper primary topic

- [Liver physiology and pathology](https://scholariq.org/topics/liver-physiology-and-pathology/)

## Paper topics

- [Liver physiology and pathology](https://scholariq.org/topics/liver-physiology-and-pathology/)
- [Cancer Mechanisms and Therapy](https://scholariq.org/topics/cancer-mechanisms-and-therapy/)
- [PI3K/AKT/mTOR signaling in cancer](https://scholariq.org/topics/pi3k-akt-mtor-signaling-in-cancer/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.