# Discovery of a Potent, Selective, and Orally Bioavailable c-Met Inhibitor: 1-(2-Hydroxy-2-methylpropyl)-<i>N</i>-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1<i>H</i>-pyrazole-4-carboxamide (AMG 458)

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/discovery-of-a-potent-selective-and-orally-bioavailable-c-met-inhibitor-1-2/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Longbin Liu,Aaron Siegmund,Ning Xi,Paula Kaplan‐Lefko,Karen Rex,April Chen,Jasmine Lin,Jodi Moriguchi,Loren Berry,Liyue Huang,Yohannes Teffera,Yajing Yang,Yihong Zhang,Steven F. Bellon,Matthew Lee,Roman Shimanovich,Annette Bak,Celia Dominguez,Mark H. Norman,Jean-Christophe Harmange,Isabelle Dussault,Tae‐Seong Kim |
| Citations | 96 |
| DOI | 10.1021/jm800401t |
| Fields | Biochemistry, Genetics and Molecular Biology,Medicine,Pharmacology, Toxicology and Pharmaceutics |
| Open Access | true |
| OA Status | green |
| OA URL | https://doi.org/10.7270/q2ff3qng |
| OpenAlex ID | https://openalex.org/W2007248897 |
| PMID | 18553959 |
| Type | article |
| Year | 2008 |

## Paper authors

- [Yajing Yang](https://scholariq.org/researchers/yajing-yang/)

## Paper primary topic

- [Liver physiology and pathology](https://scholariq.org/topics/liver-physiology-and-pathology/)

## Paper topics

- [Liver physiology and pathology](https://scholariq.org/topics/liver-physiology-and-pathology/)
- [PI3K/AKT/mTOR signaling in cancer](https://scholariq.org/topics/pi3k-akt-mtor-signaling-in-cancer/)
- [Pharmacogenetics and Drug Metabolism](https://scholariq.org/topics/pharmacogenetics-and-drug-metabolism/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.