# Discovery of AMG 193, an MTA-Cooperative PRMT5 Inhibitor for the Treatment of <i>MTAP</i>-Deleted Cancers

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/discovery-of-amg-193-an-mta-cooperative-prmt5-inhibitor-for-the-treatment-of-i/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Liping H. Pettus,Matthew P. Bourbeau,Nuria Tamayo,Albert Amegadzie,Diane Beylkin,Shon K. Booker,John Butler,Michael Frohn,Matthew R. Kaller,Todd J. Kohn,Brian A. Lanman,Kexue Li,Qingyian Liu,Vu Ma,Jose M. Medina,Ana Minatti,Patrícia Luciana da Costa Lopez,Francesco Manoni,Alex Pickrell,Nicholas A. Weires,Jan Andersson,Sanne Cowland,Sanne Glad,Ian Sarvary,M. Vestergaard,Weikun Li,Sudipa Ghimire-Rijal,Narbe Mardirossian,Susmith Mukund,Qing Chen,Mei-Chu Lo,Rachel Ngo,Jawahar Khetan,Franck Madoux,Christiana Sanders,Pooja Sharma,Paul Wang,Bernd A. Bruenner,S.J. McCloud,Manuel Antonio Díaz de León Ponce,Marcus Soto,Jan L. Wahlstrom,Fang Xie,Yajing Yang,Siyuan Liu,Hong Tan,Antonia N. Policheni,Sean Caenepeel,Katherine K. Slemmons,Brian Belmontes,Paul Hughes,Jennifer R. Allen |
| Citations | 25 |
| DOI | 10.1021/acs.jmedchem.4c03121 |
| Fields | Biochemistry, Genetics and Molecular Biology |
| Open Access | true |
| OA Status | green |
| OA URL | https://doi.org/10.7270/q2rf60x9 |
| OpenAlex ID | https://openalex.org/W4408903712 |
| PMID | 40146197 |
| Type | article |
| Year | 2025 |

## Paper authors

- [Yajing Yang](https://scholariq.org/researchers/yajing-yang/)

## Paper primary topic

- [Cancer-related gene regulation](https://scholariq.org/topics/cancer-related-gene-regulation/)

## Paper topics

- [Cancer-related gene regulation](https://scholariq.org/topics/cancer-related-gene-regulation/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.