# Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/discovery-of-gdc-0077-inavolisib-a-highly-selective-inhibitor-and-degrader-of/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Emily J. Hanan,Marie-Gabrielle Braun,Robert A. Heald,Calum MacLeod,Connie Chan,Saundra Clausen,Kyle A. Edgar,Charles Eigenbrot,Richard L. Elliott,Nicholas Endres,Lori S. Friedman,Emily Gogol,Xiaohui Gu,Rebecca Hong Thibodeau,Philip S. Jackson,James R. Kiefer,Jamie D. Knight,Michelle Nannini,Raman Narukulla,Amanda F. Pace,Jodie Pang,Hans E. Purkey,Laurent Salphati,Deepak Sampath,Stephen Schmidt,Steve Sideris,Kyung Song,Swathi Sujatha-Bhaskar,Mark Ultsch,Heidi J.A. Wallweber,Jianfeng Xin,SiewKuen Yeap,Amy Young,Yu Zhong,Steven T. Staben |
| Citations | 139 |
| DOI | 10.1021/acs.jmedchem.2c01422 |
| Fields | Biochemistry, Genetics and Molecular Biology,Medicine |
| Open Access | true |
| OA Status | green |
| OA URL | https://doi.org/10.7270/q2s46x11 |
| OpenAlex ID | https://openalex.org/W4310593433 |
| PMID | 36455032 |
| Type | article |
| Year | 2022 |

## Paper authors

- [Yu Zhong](https://scholariq.org/researchers/yu-zhong/)

## Paper primary topic

- [PI3K/AKT/mTOR signaling in cancer](https://scholariq.org/topics/pi3k-akt-mtor-signaling-in-cancer/)

## Paper topics

- [PI3K/AKT/mTOR signaling in cancer](https://scholariq.org/topics/pi3k-akt-mtor-signaling-in-cancer/)
- [Protein Degradation and Inhibitors](https://scholariq.org/topics/protein-degradation-and-inhibitors/)
- [Chronic Lymphocytic Leukemia Research](https://scholariq.org/topics/chronic-lymphocytic-leukemia-research/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.