# Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/discovery-of-jnj-74856665-a-novel-isoquinolinone-dhodh-inhibitor-for-the/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Lindsey G. DeRatt,Zhuming Zhang,Christine Pietsch,Justin S. Cisar,Xiaochun Zhang,Weixue Wang,Alexandra Tanner,Rosalie Matico,P.L. Shaffer,Edgar Jacoby,Faraz Kazmi,Neetu Shukla,Tammy L. Bush,Aaron Patrick,Ulrike Philippar,Ricardo M. Attar,James P. Edwards,Scott D. Kuduk |
| Citations | 11 |
| DOI | 10.1021/acs.jmedchem.4c00809 |
| Fields | Biochemistry, Genetics and Molecular Biology,Medicine |
| Open Access | true |
| OA Status | green |
| OA URL | https://doi.org/10.7270/q2988cq5 |
| OpenAlex ID | https://openalex.org/W4399766242 |
| PMID | 38889244 |
| Type | article |
| Year | 2024 |

## Paper authors

- [Neetu Shukla](https://scholariq.org/researchers/neetu-shukla/)

## Paper primary topic

- [Biochemical and Molecular Research](https://scholariq.org/topics/biochemical-and-molecular-research/)

## Paper topics

- [Biochemical and Molecular Research](https://scholariq.org/topics/biochemical-and-molecular-research/)
- [HIV/AIDS drug development and treatment](https://scholariq.org/topics/hiv-aids-drug-development-and-treatment/)
- [Acute Lymphoblastic Leukemia research](https://scholariq.org/topics/acute-lymphoblastic-leukemia-research/)

---
Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.