# Discovery of Ketal‐Ester Ionizable Lipid Nanoparticle with Reduced Hepatotoxicity, Enhanced Spleen Tropism for mRNA Vaccine Delivery

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/discovery-of-ketal-ester-ionizable-lipid-nanoparticle-with-reduced/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Kai Lv,Zhenlei Yu,Jing Wang,Na Li,Apeng Wang,Tiezheng Xue,Qixin Wang,Yanqin Shi,Lu Han,Wei Qin,Jiaqi Gong,Huijuan Song,Tingting Zhang,Chunyan Chang,Hua Chen,Xijun Zhong,Jianjun Ding,Rui Chen,Mingliang Liu,Weiguo Zhang,Shan Cen,Yijie Dong |
| Citations | 44 |
| DOI | 10.1002/advs.202404684 |
| Fields | Biochemistry, Genetics and Molecular Biology,Medicine |
| Open Access | true |
| OA Status | gold |
| OA URL | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.202404684 |
| OpenAlex ID | https://openalex.org/W4403299713 |
| PMID | 39387241 |
| Type | article |
| Year | 2024 |

## Paper authors

- [Jiaqi Gong](https://scholariq.org/researchers/jiaqi-gong/)

## Paper primary topic

- [RNA Interference and Gene Delivery](https://scholariq.org/topics/rna-interference-and-gene-delivery/)

## Paper topics

- [RNA Interference and Gene Delivery](https://scholariq.org/topics/rna-interference-and-gene-delivery/)
- [Viral gastroenteritis research and epidemiology](https://scholariq.org/topics/viral-gastroenteritis-research-and-epidemiology/)
- [SARS-CoV-2 and COVID-19 Research](https://scholariq.org/topics/sars-cov-2-and-covid-19-research/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.