# Discovery of KT-474─a Potent, Selective, and Orally Bioavailable IRAK4 Degrader for the Treatment of Autoimmune Diseases

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/discovery-of-kt-474-a-potent-selective-and-orally-bioavailable-irak4-degrader/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Xiaozhang Zheng,Nan Ji,Veronica A. Campbell,Anthony Slavin,Xiao Zhu,Dapeng Chen,Haojing Rong,Brad Enerson,Michele Mayo,Kirti Sharma,C. Browne,Christine R. Klaus,Haoran Li,Ginny Massa,Alice McDonald,Yatao Shi,Mike Sintchak,Stephanie Skouras,Dirk Walther,Karen Yuan,Yi Zhang,Joe Kelleher,Guang Liu,Xinbo Luo,Nello Mainolfi,Matthew M. Weiss |
| Citations | 73 |
| DOI | 10.1021/acs.jmedchem.4c01305 |
| Fields | Biochemistry, Genetics and Molecular Biology,Medicine,Neuroscience |
| Open Access | true |
| OA Status | hybrid |
| OA URL | https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01305?ref=article_openPDF |
| OpenAlex ID | https://openalex.org/W4401632083 |
| PMID | 39151120 |
| Type | article |
| Year | 2024 |

## Paper authors

- [Dapeng Chen](https://scholariq.org/researchers/dapeng-chen/)

## Paper primary topic

- [Peptidase Inhibition and Analysis](https://scholariq.org/topics/peptidase-inhibition-and-analysis/)

## Paper topics

- [Peptidase Inhibition and Analysis](https://scholariq.org/topics/peptidase-inhibition-and-analysis/)
- [RNA Interference and Gene Delivery](https://scholariq.org/topics/rna-interference-and-gene-delivery/)
- [Neuropeptides and Animal Physiology](https://scholariq.org/topics/neuropeptides-and-animal-physiology/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.