# DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/dot1l-inhibits-sirt1-mediated-epigenetic-silencing-to-maintain-leukemic-gene/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Chun‐Wei Chen,Richard P. Koche,Amit Sinha,Aniruddha J. Deshpande,Nan Zhu,Rowena Eng,John G. Doench,Haiming Xu,S. Haihua Chu,Jun Qi,Xi Wang,Christopher D. Delaney,Kathrin M. Bernt,David E. Root,William C. Hahn,James E. Bradner,Scott A Armstrong |
| Citations | 255 |
| DOI | 10.1038/nm.3832 |
| Fields | Biochemistry, Genetics and Molecular Biology |
| Open Access | true |
| OA Status | green |
| OA URL | https://www.ncbi.nlm.nih.gov/pmc/articles/4390532 |
| OpenAlex ID | https://openalex.org/W2004761725 |
| PMID | 25822366 |
| Type | article |
| Year | 2015 |

## Paper authors

- [Nan Zhu](https://scholariq.org/researchers/nan-zhu/)

## Paper journal

- [Nature Medicine](https://scholariq.org/journals/nature-medicine/)

## Paper primary topic

- [Epigenetics and DNA Methylation](https://scholariq.org/topics/epigenetics-and-dna-methylation/)

## Paper topics

- [Epigenetics and DNA Methylation](https://scholariq.org/topics/epigenetics-and-dna-methylation/)
- [Histone Deacetylase Inhibitors Research](https://scholariq.org/topics/histone-deacetylase-inhibitors-research/)
- [Protein Degradation and Inhibitors](https://scholariq.org/topics/protein-degradation-and-inhibitors/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.