# Efficacy and Safety of Fixed-Dose Esketamine Nasal Spray Combined With a New Oral Antidepressant in Treatment-Resistant Depression: Results of a Randomized, Double-Blind, Active-Controlled Study (TRANSFORM-1)

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/efficacy-and-safety-of-fixed-dose-esketamine-nasal-spray-combined-with-a-new/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Maggie Fedgchin,Madhukar H. Trivedi,Ella Daly,Rama Melkote,Rosanne Lane,Pilar Lim,Dawn Vitagliano,Pierre Blier,Maurizio Fava,Michael R. Liebowitz,Arun Ravindran,Raphaël Gaillard,Hans van den Ameele,Sheldon Preskorn,Husseini K. Manji,David Hough,Wayne C. Drevets,Jaskaran Singh |
| Citations | 597 |
| DOI | 10.1093/ijnp/pyz039 |
| Fields | Medicine,Psychology |
| Open Access | true |
| OA Status | gold |
| OA URL | https://watermark.silverchair.com/pyz039.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAqEwggKdBgkqhkiG9w0BBwagggKOMIICigIBADCCAoMGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMaQ2ZYt9794dba1VqAgEQgIICVK6b5y6TUCNHhvNhXvPO2eO8C3EI3hSe_RNK7pWKc_XDO9QZsu4axIhka-nsu7gocqBiIOqX137XMYvjAucn6IVIDC2lXkC2mA6w-si7C7IBN_0rXQ6XwuuFvlvsO8shR6liUmJ-Db8iNRvsV5P5Zid7ga1UWRP6h9cGshzNtUvAxKkQiXik4vu8iBIBGCzqLvMED2gjdKMUMIBiL50xrxtFGmRYKHEe0OJ2cqPfRJqjGn40CVLsptjNHxcs1ryBKx5VxFT1V6NUwhZPpJ6PWT3yiNTca07C3TrIv1CZmxSRvCTWlxhYY0zmXJwueWqwuqlwDWX5bKcEEP12jKmHYZgkMj-4R4GdFGLiiJoWe3nA5F2-9Vfh9A-jQbrfrVx7z1W3OQ0Vwre9GrIRrseMV2YmAyQeH6jUcZHeK_YrcjmNQc15mxVdPgDHX4BlN4_yH0tAok-IcwOMJ3f6A-WlmdBBlN8qRKHDk2tVM9KFjsPLhoFK3DcKOQAgUQeskfrmBInW6YoqVmFp44V3SJgcMUOzIVHwEj2TxcXhZXq-cJQcEtS3mcNTQtV2_nlTXE3xY7pl9kv20a4mu_roUF1Ivu4vZWYEEekhhwYEgrj4OYr8g_s2KAeU6V-D_aS3QdSWGLFOwm9oRcoDaNRxscDzfjnY9H2XuH2JrK0kINdWOKnJWkG2YuLK9kWmv-Q3XyVerGrnFwabi2JANtICsJMrzp0QDM2GxlzkzjKjC6qau1qK3JinUE7nWTPWCTmO6nS8HgmfMKwVVmre6o9mLB6BtcOOiJjJ |
| OpenAlex ID | https://openalex.org/W2961020354 |
| PMID | 31290965 |
| Type | article |
| Year | 2019 |

## Paper authors

- [Rosanne Lane](https://scholariq.org/researchers/rosanne-lane/)
- [Wayne C. Drevets](https://scholariq.org/researchers/wayne-c-drevets/)
- [Jaskaran Singh](https://scholariq.org/researchers/jaskaran-singh/)

## Paper primary topic

- [Treatment of Major Depression](https://scholariq.org/topics/treatment-of-major-depression/)

## Paper topics

- [Treatment of Major Depression](https://scholariq.org/topics/treatment-of-major-depression/)
- [Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes](https://scholariq.org/topics/anxiety-depression-psychometrics-treatment-cognitive-processes/)
- [Psychedelics and Drug Studies](https://scholariq.org/topics/psychedelics-and-drug-studies/)

---
Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.