# Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/efficacy-and-safety-of-ultrahigh-dose-methylcobalamin-in-early-stage-amyotrophic/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Ryosuke Oki,Yuishin Izumi,Koji Fujita,Ryosuke Miyamoto,Hiroyuki Nodera,Yasutaka Sato,Satoshi Sakaguchi,Hiroshi Nokihara,Kazuaki Kanai,Taiji Tsunemi,Nobutaka Hattori,Yuki Hatanaka,Masahiro Sonoo,Naoki Atsuta,Gen Sobue,Toshio Shimizu,Kazumoto Shibuya,Ken Ikeda,Osamu Kano,Kazuto Nishinaka,Yasuhiro Kojima,Masaya Oda,Kiyonobu Komai,Hitoshi Kikuchi,Nobuo Kohara,Makoto Urushitani,Yoshiaki Nakayama,Hidefumi Ito,Makiko Nagai,Kazutoshi Nishiyama,Daisuke Kuzume,Shun Shimohama,Takayoshi Shimohata,Koji Abe,Tomohiko Ishihara,Osamu Onodera,Sagiri Isose,Nobuyuki Araki,Mitsuya Morita,Kazuyuki Noda,Tatsushi Toda,Hirofumi Maruyama,Hirokazu Furuya,Satoshi Teramukai,Tatsuo Kagimura,Kensuke Noma,Hiroaki Yanagawa,Satoshi Kuwabara,Ryuji Kaji,Japan Early-Stage Trial of Ultrahigh-Dose Methylcobalamin for ALS (JETALS) Collaborators,Yusuke Osaki,Hiroki Yamazaki,Shotaro Haji,Yumi Ishida,Akari Futami,Toshiko Miyamoto,Akiyo Akaishi,Kenshi Takechi,K Maeda,Shoko Kurisu,M Yoshizawa,Nozomu Matsuda,Tomoko Nakazato,Ryoichi Nakamura,Naoki Hayashi,Akihiro Kawata,Hideki Kimura,Kota Bokuda,Akiko Tamura,Chiho Ishida,Michi Kawamoto,Hyo Kim,Jun Kawamata,Shin Hisahara,Yuichi Kimura,Toru Yamashita,Yasuyuki Ohta,Kimihito Arai,Takahiro Takeda,Tomoo Ogawa,Shingo Ikari,Yasunori Ono,Yukio Fujino |
| Citations | 85 |
| DOI | 10.1001/jamaneurol.2022.0901 |
| Fields | Medicine,Neuroscience |
| Open Access | true |
| OA Status | bronze |
| OA URL | https://jamanetwork.com/journals/jamaneurology/articlepdf/2792228/jamaneurology_oki_2022_oi_220017_1653667072.30456.pdf |
| OpenAlex ID | https://openalex.org/W4229439309 |
| PMID | 35532908 |
| Type | article |
| Year | 2022 |

## Paper authors

- [Hiroaki Yanagawa](https://scholariq.org/researchers/hiroaki-yanagawa/)

## Paper journal

- [JAMA Neurology](https://scholariq.org/journals/jama-neurology/)

## Paper primary topic

- [Amyotrophic Lateral Sclerosis Research](https://scholariq.org/topics/amyotrophic-lateral-sclerosis-research/)

## Paper topics

- [Amyotrophic Lateral Sclerosis Research](https://scholariq.org/topics/amyotrophic-lateral-sclerosis-research/)
- [Neurogenetic and Muscular Disorders Research](https://scholariq.org/topics/neurogenetic-and-muscular-disorders-research/)
- [Genetic Neurodegenerative Diseases](https://scholariq.org/topics/genetic-neurodegenerative-diseases/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.