# Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACE-TIMI 57): a randomised, placebo-controlled, dose-ranging, phase 2 study

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/efficacy-safety-and-tolerability-of-a-monoclonal-antibody-to-proprotein-2/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Robert P. Giugliano,Nihar R. Desai,Payal Kohli,William J. Rogers,Ransi Somaratne,Fannie Huang,Thomas Liu,Satishkumar Mohanavelu,Elaine Hoffman,Shannon T McDonald,Timothy E Abrahamsen,Scott M. Wasserman,Robert C. Scott,Marc S. Sabatine |
| Citations | 424 |
| DOI | 10.1016/s0140-6736(12)61770-x |
| Fields | Immunology and Microbiology,Medicine |
| Open Access | false |
| OA Status | closed |
| OpenAlex ID | https://openalex.org/W2108956796 |
| PMID | 23141813 |
| Type | article |
| Year | 2012 |

## Paper authors

- [Nihar R. Desai](https://scholariq.org/researchers/nihar-r-desai/)
- [William J. Rogers](https://scholariq.org/researchers/william-j-rogers/)
- [Marc S. Sabatine](https://scholariq.org/researchers/marc-s-sabatine/)

## Paper journal

- [The Lancet](https://scholariq.org/journals/the-lancet/)

## Paper primary topic

- [Lipoproteins and Cardiovascular Health](https://scholariq.org/topics/lipoproteins-and-cardiovascular-health/)

## Paper topics

- [Lipoproteins and Cardiovascular Health](https://scholariq.org/topics/lipoproteins-and-cardiovascular-health/)
- [Atherosclerosis and Cardiovascular Diseases](https://scholariq.org/topics/atherosclerosis-and-cardiovascular-diseases/)
- [Diabetes Treatment and Management](https://scholariq.org/topics/diabetes-treatment-and-management/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.