# EGFR-mutant transformed small cell lung cancer harbors intratumoral heterogeneity targetable with MEK inhibitor combination therapy

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/egfr-mutant-transformed-small-cell-lung-cancer-harbors-intratumoral/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Atsuko Ogino,Amir Vajdi,Xinmeng Jasmine Mu,Navin R. Mahadevan,Kenneth Ngo,Matthew A. Booker,Paloma Cejas,Jeffrey J. Okoro,Man Xu,Benjamin F. Springer,Benjamin K. Eschle,Cameron Messier,Stephen Wang,Sudeepa Syamala,Rubii M. Tamen,Anika E. Adeni,Emily S. Chambers,Israel Canadas,Tran C. Thai,Camilla L. Christensen,Cheng Xu,Patrick H. Lizotte,Geoffrey R. Oxnard,Hideo Watanabe,Henry W. Long,Prafulla C. Gokhale,Cloud P. Paweletz,Lynette M. Sholl,Matthew G. Oser,David A. Barbie,Michael Tolstorukov,Pasi A. Jänne |
| Citations | 1 |
| DOI | 10.1172/jci.insight.197008 |
| Fields | Biochemistry, Genetics and Molecular Biology,Medicine |
| Open Access | true |
| OA Status | gold |
| OA URL | http://insight.jci.org/articles/view/197008/files/pdf |
| OpenAlex ID | https://openalex.org/W7125370641 |
| PMID | 41574603 |
| Type | article |
| Year | 2026 |

## Paper authors

- [Michael Tolstorukov](https://scholariq.org/researchers/michael-tolstorukov/)
- [Hideo Watanabe](https://scholariq.org/researchers/hideo-watanabe/)
- [Xinmeng Jasmine Mu](https://scholariq.org/researchers/xinmeng-jasmine-mu/)
- [Geoffrey R. Oxnard](https://scholariq.org/researchers/geoffrey-r-oxnard/)
- [Cloud P. Paweletz](https://scholariq.org/researchers/cloud-p-paweletz/)

## Paper funders

- [U.S. Department of Defense](https://scholariq.org/funders/u-s-department-of-defense/)
- [National Institutes of Health](https://scholariq.org/funders/national-institutes-of-health/)
- [National Cancer Institute](https://scholariq.org/funders/national-cancer-institute/)

## Paper journal

- [JCI Insight](https://scholariq.org/journals/jci-insight/)

## Paper primary topic

- [Lung Cancer Research Studies](https://scholariq.org/topics/lung-cancer-research-studies/)

## Paper topics

- [Lung Cancer Research Studies](https://scholariq.org/topics/lung-cancer-research-studies/)
- [Lung Cancer Treatments and Mutations](https://scholariq.org/topics/lung-cancer-treatments-and-mutations/)
- [Chromatin Remodeling and Cancer](https://scholariq.org/topics/chromatin-remodeling-and-cancer/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.