# Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/fc-optimized-anti-cd25-depletes-tumor-infiltrating-regulatory-t-cells-and/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Frederick Arce Vargas,Andrew J.S. Furness,Isabelle Solomon,Kroopa Joshi,Leila Mekkaoui,Marta H. Lesko,Enrique Miranda,Rony Dahan,Andrew Georgiou,Anna Śledzińska,Assma Ben Aïssa,Dafne Franz,Mariana Werner Sunderland,Yien Ning Sophia Wong,Jake Y. Henry,Tim O’Brien,David Nicol,Ben Challacombe,Stephen A. Beers,Lavinia Spain,Andrew Wotherspoon,Nicholas Francis,Myles Smith,D. Strauß,Andrew J. Hayes,Aspasia Soultati,Mark Stares,Lavinia Spain,Joanna Lynch,Nicos Fotiadis,Archana Fernando,Steve Hazell,Ashish Chandra,Lisa Pickering,Sarah Rudman,Simon Chowdhury,Charles Swanton,Mariam Jamal‐Hanjani,Selvaraju Veeriah,Seema Shafi,Justyna Czyzewska-Khan,Diana Johnson,Joanne Laycock,Leticia Bosshard‐Carter,Gerald Goh,Rachel Rosenthal,Pat Gorman,Nirupa Murugaesu,Robert E. Hynds,Gareth A. Wilson,Nicolai J. Birkbak,Thomas B.K. Watkins,Nicholas McGranahan,Stuart Horswell,Richard Mitter,Mickael Escudero,Aengus Stewart,Peter Van Loo,Andrew Rowan,Hang Xu,Samra Turajlic,Crispin T. Hiley,Christopher Abbosh,Jacki Goldman,Richard Stone,Tamara Denner,Nik Matthews,Greg Elgar,Sophia Ward,Jennifer Biggs,Marta Costa,Sharmin Begum,Ben Phillimore,Tim Chambers,Emma Nye,Sofia Graca,Maise Al Bakir,John A. Hartley,Helen L. Lowe,Javier Herrero,David Lawrence,Martin Hayward,Nikolaos Panagiotopoulos,Shyam Kolvekar,Mary Falzon,Elaine Borg,Celia Simeon,Gemma Hector,Amy Smith,Marie Aranda,Marco Novelli,Dahmane Oukrif,Sam M. Janes,Ricky M. Thakrar,Martin Förster,Tanya Ahmad,Siow Ming Lee,Dionysis Papadatos-Pastos,Dawn Carnell,R. Mendes |
| Citations | 434 |
| DOI | 10.1016/j.immuni.2017.03.013 |
| Fields | Immunology and Microbiology,Medicine |
| Open Access | true |
| OA Status | hybrid |
| OA URL | http://www.cell.com/article/S1074761317301231/pdf |
| OpenAlex ID | https://openalex.org/W2607137647 |
| PMID | 28410988 |
| Type | article |
| Year | 2017 |

## Paper authors

- [Alison Edwards](https://scholariq.org/researchers/alison-edwards/)

## Paper primary topic

- [Immune Cell Function and Interaction](https://scholariq.org/topics/immune-cell-function-and-interaction/)

## Paper topics

- [Immune Cell Function and Interaction](https://scholariq.org/topics/immune-cell-function-and-interaction/)
- [Monoclonal and Polyclonal Antibodies Research](https://scholariq.org/topics/monoclonal-and-polyclonal-antibodies-research/)
- [Immunotherapy and Immune Responses](https://scholariq.org/topics/immunotherapy-and-immune-responses/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.