# First-in-human phase I study of copanlisib (BAY 80-6946), an intravenous pan-class I phosphatidylinositol 3-kinase inhibitor, in patients with advanced solid tumors and non-Hodgkin's lymphomas

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/first-in-human-phase-i-study-of-copanlisib-bay-80-6946-an-intravenous-pan-class/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Amita Patnaik,Leonard J. Appleman,Anthony W. Tolcher,Kyriakos P. Papadopoulos,Muralidhar Beeram,Drew Rasco,Glen J. Weiss,Jasgit C. Sachdev,Manpreet Chadha,Maddie Fulk,Samuel Ejadi,James M. Mountz,Michael T. Lotze,Frederico G. S. Toledo,Edward Chu,Michael Jeffers,Carol E. Peña,Chenjing Xia,Stefanie Reif,Isabelle Genvresse,Ramesh K. Ramanathan |
| Citations | 237 |
| DOI | 10.1093/annonc/mdw282 |
| Fields | Biochemistry, Genetics and Molecular Biology,Medicine |
| Open Access | true |
| OA Status | bronze |
| OA URL | https://academic.oup.com/annonc/article-pdf/27/10/1928/24168065/mdw282.pdf |
| OpenAlex ID | https://openalex.org/W2525724642 |
| PMID | 27672108 |
| Type | article |
| Year | 2016 |

## Paper authors

- [Edward Chu](https://scholariq.org/researchers/edward-chu/)

## Paper journal

- [Annals of Oncology](https://scholariq.org/journals/annals-of-oncology/)

## Paper primary topic

- [PI3K/AKT/mTOR signaling in cancer](https://scholariq.org/topics/pi3k-akt-mtor-signaling-in-cancer/)

## Paper topics

- [PI3K/AKT/mTOR signaling in cancer](https://scholariq.org/topics/pi3k-akt-mtor-signaling-in-cancer/)
- [Metabolism, Diabetes, and Cancer](https://scholariq.org/topics/metabolism-diabetes-and-cancer/)
- [Chronic Lymphocytic Leukemia Research](https://scholariq.org/topics/chronic-lymphocytic-leukemia-research/)

---
Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.