# Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/germline-mutations-affecting-the-proofreading-domains-of-pole-and-pold1/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Claire Palles,Jean‐Baptiste Cazier,Kimberley Howarth,Enric Domingo,Angela M. Jones,Peter Broderick,Zoe Kemp,Sarah L. Spain,Estrella Guarino,Israel Salguero,Amy L. Sherborne,Daniel Chubb,Luis G. Carvajal‐Carmona,Yusanne Ma,Kulvinder Kaur,Sara E. Dobbins,Ella Barclay,Maggie Gorman,Lynn Martin,Michal Kováč,Sean Humphray,Anneke Lucassen,Chris Holmes,David L. Bentley,Peter Donnelly,Jenny C. Taylor,Christos Petridis,Rebecca Roylance,Elinor J. Sawyer,David Kerr,Susan K. Clark,Jonathan M. Grimes,Stephen Kearsey,Huw Thomas,Gil McVean,Richard S. Houlston,Ian Tomlinson |
| Citations | 1,014 |
| DOI | 10.1038/ng.2503 |
| Fields | Biochemistry, Genetics and Molecular Biology,Medicine |
| Open Access | true |
| OA Status | green |
| OA URL | https://ddfv.ufv.es/bitstreams/75576dbc-bacf-4d4b-8bce-c63fb620ae58/download |
| OpenAlex ID | https://openalex.org/W2145606954 |
| PMID | 23263490 |
| Type | article |
| Year | 2012 |

## Paper authors

- [Elinor J. Sawyer](https://scholariq.org/researchers/elinor-j-sawyer/)

## Paper primary topic

- [Genetic factors in colorectal cancer](https://scholariq.org/topics/genetic-factors-in-colorectal-cancer/)

## Paper topics

- [Genetic factors in colorectal cancer](https://scholariq.org/topics/genetic-factors-in-colorectal-cancer/)
- [Colorectal Cancer Treatments and Studies](https://scholariq.org/topics/colorectal-cancer-treatments-and-studies/)
- [Cancer, Lipids, and Metabolism](https://scholariq.org/topics/cancer-lipids-and-metabolism/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.