# GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/guide-seq-enables-genome-wide-profiling-of-off-target-cleavage-by-crispr-cas/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Shengdar Q. Tsai,Zongli Zheng,Nathalie T. Nguyen,Matthew Liebers,Ved V. Topkar,Vishal Thapar,Nicolas Wyvekens,Cyd Khayter,A. John Iafrate,Long P. Le,Martin J. Aryee,J. Keith Joung |
| Citations | 2,354 |
| DOI | 10.1038/nbt.3117 |
| Fields | Biochemistry, Genetics and Molecular Biology |
| Open Access | true |
| OA Status | green |
| OA URL | http://nrs.harvard.edu/urn-3:HUL.InstRepos:21460330 |
| OpenAlex ID | https://openalex.org/W2003797386 |
| PMID | 25513782 |
| Type | article |
| Year | 2014 |

## Paper authors

- [A. John Iafrate](https://scholariq.org/researchers/a-john-iafrate/)

## Paper primary topic

- [CRISPR and Genetic Engineering](https://scholariq.org/topics/crispr-and-genetic-engineering/)

## Paper topics

- [CRISPR and Genetic Engineering](https://scholariq.org/topics/crispr-and-genetic-engineering/)
- [RNA regulation and disease](https://scholariq.org/topics/rna-regulation-and-disease/)
- [Advanced biosensing and bioanalysis techniques](https://scholariq.org/topics/advanced-biosensing-and-bioanalysis-techniques/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.