# Impact of Natural IRS-1 Mutations on Insulin Signals: Mutations of IRS-1 in the PTB Domain and Near SH2 Protein Binding Sites Result in Impaired Function at Different Steps of IRS-1 Signaling

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/impact-of-natural-irs-1-mutations-on-insulin-signals-mutations-of-irs-1-in-the/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Ryohei Yoshimura,Eiichi Araki,Sachiko Ura,M. Todaka,Kaku Tsuruzoe,NOBORU FURUKAWA,Hiroyuki Motoshima,Kazuaki Yoshizato,Kengo Kaneko,Kohji Matsuda,Hideki Kishikawa,Motoaki Shichiri |
| Citations | 56 |
| DOI | 10.2337/diab.46.6.929 |
| Fields | Biochemistry, Genetics and Molecular Biology |
| Open Access | false |
| OA Status | closed |
| OpenAlex ID | https://openalex.org/W2073217090 |
| PMID | 9166661 |
| Type | article |
| Year | 1997 |

## Paper authors

- [Hideki Kishikawa](https://scholariq.org/researchers/hideki-kishikawa/)

## Paper primary topic

- [Metabolism, Diabetes, and Cancer](https://scholariq.org/topics/metabolism-diabetes-and-cancer/)

## Paper topics

- [Metabolism, Diabetes, and Cancer](https://scholariq.org/topics/metabolism-diabetes-and-cancer/)
- [Protein Kinase Regulation and GTPase Signaling](https://scholariq.org/topics/protein-kinase-regulation-and-gtpase-signaling/)
- [PI3K/AKT/mTOR signaling in cancer](https://scholariq.org/topics/pi3k-akt-mtor-signaling-in-cancer/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.