# IMPORTANCE trial: a provisional study-design of a single-center, phase II, double-blinded, placebo-controlled, randomized, 4-week study to compare the efficacy and safety of intranasal esketamine in chronic opioid refractory pain \[version 1; peer review: 2 approved\]

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/importance-trial-a-provisional-study-design-of-a-single-center-phase-ii-double-2/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Mauricio Fernandes,Magdalena Schelotto,Philipp M. Doldi,Geórgia K. M. Milani,Ariza Manzano A,Perera Valdivia D,Winter Matos A,Hamdy Abdelrahim Y,Hamad Bek S,Benito K. Benitez,Romanelli Tavares,Abdulrahim Basendwah,Albuquerque Sousa L,Nathalia Villaça Xavier,Zertuche Maldonado T,Toyomi de Oliveira S,Melisa Chaker,Menon Miyake M,Uygur Kucukseymen E,Kinza Waqar,O Alkhozondar,Bernardo da Silva R,Guillermo Droppelmann,Vaz de Macedo A,Ricardo Kenithi Nakamura,Felipe Fregni |
| Citations | 0 |
| Fields | Medicine |
| Open Access | false |
| OA Status | closed |
| OpenAlex ID | https://openalex.org/W3135960288 |
| Type | article |
| Year | 2021 |

## Paper authors

- [Mauricio Fernandes](https://scholariq.org/researchers/mauricio-fernandes/)

## Paper primary topic

- [Pain Mechanisms and Treatments](https://scholariq.org/topics/pain-mechanisms-and-treatments/)

## Paper topics

- [Pain Mechanisms and Treatments](https://scholariq.org/topics/pain-mechanisms-and-treatments/)
- [Treatment of Major Depression](https://scholariq.org/topics/treatment-of-major-depression/)
- [Pain Management and Opioid Use](https://scholariq.org/topics/pain-management-and-opioid-use/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.