# IMPORTANCE trial: a provisional study-design of a single-center, phase II, double-blinded, placebo-controlled, randomized, 4-week study to compare the efficacy and safety of intranasal esketamine in chronic opioid refractory pain

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/importance-trial-a-provisional-study-design-of-a-single-center-phase-ii-double/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Mauricio Fernandes,Magdalena Schelotto,Philipp M. Doldi,Giovanna Milani,Abul Andrés Ariza Manzano,Doriam Perera Valdivia,Alexandra Winter-Matos,Yasmin Hamdy Abdelrahim,Shaza Ahmed Hamad Bek,Benito K. Benitez,Vanessa Luiza Romanelli Tavares,Abdulrahim Basendwah,Luís Henrique Albuquerque Sousa,Naiara Faria Xavier,Tania Zertuche-Maldonado,Sarah Toyomi de Oliveira,Melisa Chaker,Michelle Menon Miyake,Elif Uygur-Kucukseymen,Kinza Waqar,O Alkhozondar,Ricardo Bernardo da Silva,Guilhermo Droppelmann,Antônio Vaz de Macedo,Rui Nakamura,Felipe Fregni |
| Citations | 15 |
| DOI | 10.12688/f1000research.27809.1 |
| Fields | Medicine |
| Open Access | true |
| OA Status | gold |
| OA URL | https://doi.org/10.12688/f1000research.27809.1 |
| OpenAlex ID | https://openalex.org/W3125524977 |
| PMID | 33732434 |
| Type | article |
| Year | 2021 |

## Paper authors

- [Mauricio Fernandes](https://scholariq.org/researchers/mauricio-fernandes/)

## Paper journal

- [F1000Research](https://scholariq.org/journals/f1000research/)

## Paper primary topic

- [Pain Management and Opioid Use](https://scholariq.org/topics/pain-management-and-opioid-use/)

## Paper topics

- [Pain Management and Opioid Use](https://scholariq.org/topics/pain-management-and-opioid-use/)
- [Pain Mechanisms and Treatments](https://scholariq.org/topics/pain-mechanisms-and-treatments/)
- [Treatment of Major Depression](https://scholariq.org/topics/treatment-of-major-depression/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.