# Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these agents in vitro and in vivo

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/inhibition-of-cdk8-19-mediator-kinase-potentiates-her2-targeting-drugs-and/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Xiaokai Ding,Amanda C. Sharko,Martina S.J. McDermott,Gary P. Schools,Alexander A. Chumanevich,Hao Ji,Jing Li,Li Zhang,Zachary T. Mack,Vitali Sikirzhytski,Michael Shtutman,Laura Ivers,Norma O’Donovan,John Crown,Balázs Győrffy,Mengqian Chen,Igor B. Roninson,Eugenia V. Broude |
| Citations | 55 |
| DOI | 10.1073/pnas.2201073119 |
| Fields | Biochemistry, Genetics and Molecular Biology,Medicine |
| Open Access | true |
| OA Status | green |
| OA URL | https://www.ncbi.nlm.nih.gov/pmc/articles/9371674 |
| OpenAlex ID | https://openalex.org/W4289261827 |
| PMID | 35914167 |
| Type | article |
| Year | 2022 |

## Paper authors

- [Xiaokai Ding](https://scholariq.org/researchers/xiaokai-ding/)

## Paper journal

- [Proceedings of the National Academy of Sciences](https://scholariq.org/journals/proceedings-of-the-national-academy-of-sciences/)

## Paper primary topic

- [Cancer-related gene regulation](https://scholariq.org/topics/cancer-related-gene-regulation/)

## Paper topics

- [Cancer-related gene regulation](https://scholariq.org/topics/cancer-related-gene-regulation/)
- [Peptidase Inhibition and Analysis](https://scholariq.org/topics/peptidase-inhibition-and-analysis/)
- [Ubiquitin and proteasome pathways](https://scholariq.org/topics/ubiquitin-and-proteasome-pathways/)

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