# Lactate activates trained immunity by fueling the tricarboxylic acid cycle and regulating histone lactylation

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/lactate-activates-trained-immunity-by-fueling-the-tricarboxylic-acid-cycle-and/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Huanhuan Cai,Xueyuan Chen,Yan Liu,Ying-Bo Chen,Gechang Zhong,Xiaoyu Chen,Shuo Rong,Hao Zeng,Lin Zhang,Zelong Li,Aihua Liao,Xiangtai Zeng,Wei Xiong,Cihang Guo,Yanfang Zhu,Ke‐Qiong Deng,Hong Ren,Huan Yan,Zeng Cai,Ke Xu,Li Zhou,Zhibing Lu,Fubing Wang,Shi Liu |
| Citations | 75 |
| DOI | 10.1038/s41467-025-58563-2 |
| Fields | Biochemistry, Genetics and Molecular Biology,Immunology and Microbiology |
| Open Access | true |
| OA Status | gold |
| OA URL | https://www.nature.com/articles/s41467-025-58563-2.pdf |
| OpenAlex ID | https://openalex.org/W4409177944 |
| PMID | 40185732 |
| Type | article |
| Year | 2025 |

## Paper authors

- [Hong Ren](https://scholariq.org/researchers/hong-ren-2/)

## Paper journal

- [Nature Communications](https://scholariq.org/journals/nature-communications/)

## Paper primary topic

- [Immune responses and vaccinations](https://scholariq.org/topics/immune-responses-and-vaccinations/)

## Paper topics

- [Immune responses and vaccinations](https://scholariq.org/topics/immune-responses-and-vaccinations/)
- [Diabetes and associated disorders](https://scholariq.org/topics/diabetes-and-associated-disorders/)
- [Immune cells in cancer](https://scholariq.org/topics/immune-cells-in-cancer/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.