# Lenvatinib plus pembrolizumab versus lenvatinib plus placebo for advanced hepatocellular carcinoma (LEAP-002): a randomised, double-blind, phase 3 trial

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/lenvatinib-plus-pembrolizumab-versus-lenvatinib-plus-placebo-for-advanced/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Josep M. Llovet,Masatoshi Kudo,Philippe Merle,Tim Meyer,Shukui Qin,Masafumi Ikeda,Ruocai Xu,Julien Edeline,Baek‐Yeol Ryoo,Zhenggang Ren,Gianluca Masi,Mariusz Kwiatkowski,Ho Yeong Lim,Jee Hyun Kim,В. В. Бредер,Hiromitsu Kumada,Ann‐Lii Cheng,Peter R. Galle,Shuichi Kaneko,Anran Wang,Kalgi Mody,Corina E. Dutcus,Leonid Dubrovsky,Abby B. Siegel,Richard S. Finn,Simone I. Strasser,Alexander Thompson,Aflah Roohullah,William Sievert,Vladimir Andelkovic,Jennifer J. Knox,Janine M. Davies,Jamil Asselah,Mayur Brahmania,Habeeb Majeed,Luis J. Villanueva-Rivera,Patricio Yañez Weber,Marcelo Garrido,Gonzalo Pizarro,Nicolás Yáñez,Ruocai Xu,Shuangyan Ou,Zhenggang Ren,Hongming Pan,Zhiqiang Meng,Kangsheng Gu,Xi Chen,Tao Zhang,Chunyi Hao,Peiguo Cao,Yabing Guo,Shukui Qin,Juxiang Xiao,Weijia Fang,Xin Wang,Yuxian Bai,Xiaoming Chen,Dong Yan,Hong Zhao,Jieer Ying,Carlos Bonilla,Olga Urrego,Ángela R. Zambrano,Mauricio Lema,Juan Carlos Restrepo,Andrés F. Cardona,Sandra Franco Millan,Madiedo Oscar,Víctor Ramos,Philippe Merle,Samuel Lesourd,Julien Edeline,Jean–Pierre Bronowicki,Marc Bourlière,Stéphane Cattan,Mohamed Bouattour,Laurent Mineur,Hélène Regnault,Barbara Dauvois,Kornelius Schulze,Gunnar Folprecht,Andreas Geier,Oliver Waidmann,Fabian Finkelmeier,Marino Venerito,Marie‐Luise Berres,Thomas Berg,Christian M. Lange,Hartmut Schmidt,Dirk Waldschmidt,Michael Bitzer,Ray McDermott,Austin G. Duffy,Gianluca Masi,Vittorina Zagonel,Giuseppe Tonini,Fabio Piscaglia,Stefania Gori,Mimma Rizzo,Elisa Biscaldi |
| Citations | 435 |
| DOI | 10.1016/s1470-2045(23)00469-2 |
| Fields | Medicine |
| Open Access | true |
| OA Status | green |
| OA URL | https://discovery.ucl.ac.uk/10187246/7/Meyer_Lenvatinib%20plus%20pembrolizumab%20versus%20lenvatinib%20plus%20placebo%20for%20advanced%20hepatocellular%20carcinoma_AAM2.pdf |
| OpenAlex ID | https://openalex.org/W4389074118 |
| PMID | 38039993 |
| Type | article |
| Year | 2023 |

## Paper authors

- [Manabu Morimoto](https://scholariq.org/researchers/manabu-morimoto/)

## Paper journal

- [The Lancet Oncology](https://scholariq.org/journals/the-lancet-oncology/)

## Paper primary topic

- [Hepatocellular Carcinoma Treatment and Prognosis](https://scholariq.org/topics/hepatocellular-carcinoma-treatment-and-prognosis/)

## Paper topics

- [Hepatocellular Carcinoma Treatment and Prognosis](https://scholariq.org/topics/hepatocellular-carcinoma-treatment-and-prognosis/)
- [Cholangiocarcinoma and Gallbladder Cancer Studies](https://scholariq.org/topics/cholangiocarcinoma-and-gallbladder-cancer-studies/)
- [Liver physiology and pathology](https://scholariq.org/topics/liver-physiology-and-pathology/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.