# Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/mammalian-target-of-rapamycin-up-regulation-of-pyruvate-kinase-isoenzyme-type-m2/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Qian Sun,Xinxin Chen,Jianhui Ma,Haiyong Peng,Fang Wang,Xiaojun Zha,Yanan Wang,Yanling Jing,Hong-Wang Yang,Rongrong Chen,Long Chang,Yu Zhang,June Goto,Hiroaki Onda,Tong Chen,Ming‐Rong Wang,Youyong Lu,Han You,David J. Kwiatkowski,Hongbing Zhang |
| Citations | 578 |
| DOI | 10.1073/pnas.1014769108 |
| Fields | Biochemistry, Genetics and Molecular Biology,Medicine |
| Open Access | true |
| OA Status | bronze |
| OA URL | https://www.pnas.org/content/pnas/108/10/4129.full.pdf |
| OpenAlex ID | https://openalex.org/W1967980682 |
| PMID | 21325052 |
| Type | article |
| Year | 2011 |

## Paper authors

- [Fang Wang](https://scholariq.org/researchers/fang-wang-2/)

## Paper journal

- [Proceedings of the National Academy of Sciences](https://scholariq.org/journals/proceedings-of-the-national-academy-of-sciences/)

## Paper primary topic

- [Cancer, Hypoxia, and Metabolism](https://scholariq.org/topics/cancer-hypoxia-and-metabolism/)

## Paper topics

- [Cancer, Hypoxia, and Metabolism](https://scholariq.org/topics/cancer-hypoxia-and-metabolism/)
- [PI3K/AKT/mTOR signaling in cancer](https://scholariq.org/topics/pi3k-akt-mtor-signaling-in-cancer/)
- [Tuberous Sclerosis Complex Research](https://scholariq.org/topics/tuberous-sclerosis-complex-research/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.