# MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with <i>MTAP</i> -Deleted Cancer

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/mrtx1719-is-an-mta-cooperative-prmt5-inhibitor-that-exhibits-synthetic-lethality/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Lars D. Engstrom,Ruth Aranda,Laura Waters,Krystal Moya,Vickie Bowcut,Laura Vegar,David Trinh,Allan Hebbert,Christopher R. Smith,Svitlana Kulyk,J. David Lawson,Leo He,Laura D. Hover,Julio Fernandez-Banet,Jill Hallin,Darin Vanderpool,David M. Briere,Alice Blaj,Matthew A. Marx,Jordi Rodón,Michael Offin,Kathryn C. Arbour,Melissa L. Johnson,David J. Kwiatkowski,Pasi A. Jänne,Candace L. Haddox,Kyriakos P. Papadopoulos,Jason T. Henry,Konstantinos Leventakos,James G. Christensen,Ronald Shazer,Peter Olson |
| Citations | 204 |
| DOI | 10.1158/2159-8290.cd-23-0669 |
| Fields | Biochemistry, Genetics and Molecular Biology,Neuroscience |
| Open Access | true |
| OA Status | hybrid |
| OA URL | https://aacrjournals.org/cancerdiscovery/article-pdf/doi/10.1158/2159-8290.CD-23-0669/3355023/cd-23-0669.pdf |
| OpenAlex ID | https://openalex.org/W4385650986 |
| PMID | 37552839 |
| Type | article |
| Year | 2023 |

## Paper authors

- [Konstantinos Leventakos](https://scholariq.org/researchers/konstantinos-leventakos/)
- [Pasi A. Jänne](https://scholariq.org/researchers/pasi-a-janne/)

## Paper journal

- [Cancer Discovery](https://scholariq.org/journals/cancer-discovery/)

## Paper primary topic

- [Cancer-related gene regulation](https://scholariq.org/topics/cancer-related-gene-regulation/)

## Paper topics

- [Cancer-related gene regulation](https://scholariq.org/topics/cancer-related-gene-regulation/)
- [Epigenetics and DNA Methylation](https://scholariq.org/topics/epigenetics-and-dna-methylation/)
- [Nuclear Receptors and Signaling](https://scholariq.org/topics/nuclear-receptors-and-signaling/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.