# Novel Inhibitors of DNA Gyrase:  3D Structure Based Biased Needle Screening, Hit Validation by Biophysical Methods, and 3D Guided Optimization. A Promising Alternative to Random Screening

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/novel-inhibitors-of-dna-gyrase-3d-structure-based-biased-needle-screening-hit/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Hans-Joachim Boehm,Markus Boehringer,Daniel Bur,Hans Gmuender,Walter Huber,Werner Klaus,Dirk Kostrewa,Holger Kuehne,Thomas Luebbers,Nathalie Meunier-Keller,Francis Mueller |
| Citations | 379 |
| DOI | 10.1021/jm000017s |
| Fields | Biochemistry, Genetics and Molecular Biology,Medicine |
| Open Access | false |
| OA Status | closed |
| OpenAlex ID | https://openalex.org/W2014989916 |
| PMID | 10893304 |
| Type | article |
| Year | 2000 |

## Paper authors

- [Walter Huber](https://scholariq.org/researchers/walter-huber/)

## Paper primary topic

- [Cancer therapeutics and mechanisms](https://scholariq.org/topics/cancer-therapeutics-and-mechanisms/)

## Paper topics

- [Cancer therapeutics and mechanisms](https://scholariq.org/topics/cancer-therapeutics-and-mechanisms/)
- [HIV/AIDS drug development and treatment](https://scholariq.org/topics/hiv-aids-drug-development-and-treatment/)
- [Antibiotic Resistance in Bacteria](https://scholariq.org/topics/antibiotic-resistance-in-bacteria/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.