# Overcoming Acquired Resistance to AZD9291, A Third-Generation EGFR Inhibitor, through Modulation of MEK/ERK-Dependent Bim and Mcl-1 Degradation

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/overcoming-acquired-resistance-to-azd9291-a-third-generation-egfr-inhibitor/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Puyu Shi,You-Take Oh,Liang Deng,Guojing Zhang,Guoqing Qian,Shuo Zhang,Hui Ren,Grant Wu,Benjamin Legendre,Emily Anderson,Suresh S. Ramalingam,Taofeek K. Owonikoko,Mingwei Chen,Shi‐Yong Sun |
| Citations | 145 |
| DOI | 10.1158/1078-0432.ccr-17-1574 |
| Fields | Biochemistry, Genetics and Molecular Biology,Medicine |
| Open Access | true |
| OA Status | green |
| OA URL | https://www.ncbi.nlm.nih.gov/pmc/articles/5668147 |
| OpenAlex ID | https://openalex.org/W2739786760 |
| PMID | 28765329 |
| Type | article |
| Year | 2017 |

## Paper authors

- [Hui Ren](https://scholariq.org/researchers/hui-ren/)

## Paper journal

- [Clinical Cancer Research](https://scholariq.org/journals/clinical-cancer-research/)

## Paper primary topic

- [Lung Cancer Treatments and Mutations](https://scholariq.org/topics/lung-cancer-treatments-and-mutations/)

## Paper topics

- [Lung Cancer Treatments and Mutations](https://scholariq.org/topics/lung-cancer-treatments-and-mutations/)
- [Melanoma and MAPK Pathways](https://scholariq.org/topics/melanoma-and-mapk-pathways/)
- [Cancer therapeutics and mechanisms](https://scholariq.org/topics/cancer-therapeutics-and-mechanisms/)

---
Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.