# Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parallel-group, phase II-III, randomised, superiority study (CAIRO6)

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/perioperative-systemic-therapy-and-cytoreductive-surgery-with-hipec-versus/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Koen P. Rovers,Checca Bakkers,Geert A. Simkens,Jacobus W. A. Burger,Simon W. Nienhuijs,Geert-Jan Creemers,Anna M.J. Thijs,Alexandra R. M. Brandt‐Kerkhof,Eva V. E. Madsen,Ninos Ayez,Nadine L. de Boer,Esther van Meerten,Jurriaan B. Tuynman,Miranda Kusters,Nina R. Sluiter,Henk M.W. Verheul,Hans J. van der Vliet,Marinus J. Wiezer,Djamila Boerma,Emma C. E. Wassenaar,Maartje Los,Cornelis B. Hunting,Arend G. J. Aalbers,Niels F.M. Kok,Koert F.D. Kuhlmann,Henk Boot,Myriam Chalabi,Schelto Kruijff,Lukas B. Been,Robert J. van Ginkel,Derk Jan A. de Groot,Rudolf S.N. Fehrmann,Johannes H.W. de Wilt,Andreas J. A. Bremers,Philip R. de Reuver,Sandra A. Radema,Karin H. Herbschleb,Wilhelmina M. U. van Grevenstein,Arjen J. Witkamp,Miriam Koopman,Nadia Haj Mohammad,Eino B. van Duyn,W. J. B. Mastboom,Leonie J. Mekenkamp,Joost Nederend,Max J. Lahaye,Pétur Snæbjörnsson,Cornelis Verhoef,Hanneke W.M. van Laarhoven,Aeilko H. Zwinderman,Jeanette M. Bouma,Onno Kranenburg,Iris van ’t Erve,Remond J.A. Fijneman,Marcel G. W. Dijkgraaf,Patrick Hemmer,Cornelis J.A. Punt,Pieter J. Tanis,Ignace H. J. T. de Hingh,Dutch Peritoneal Oncology Group (DPOG),Dutch Colorectal Cancer Group (DCCG) |
| Citations | 111 |
| DOI | 10.1186/s12885-019-5545-0 |
| Fields | Medicine |
| Open Access | true |
| OA Status | gold |
| OA URL | https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-019-5545-0 |
| OpenAlex ID | https://openalex.org/W2941885434 |
| PMID | 31023318 |
| Type | article |
| Year | 2019 |

## Paper authors

- [Marinus J. Wiezer](https://scholariq.org/researchers/marinus-j-wiezer/)

## Paper journal

- [BMC Cancer](https://scholariq.org/journals/bmc-cancer/)

## Paper primary topic

- [Intraperitoneal and Appendiceal Malignancies](https://scholariq.org/topics/intraperitoneal-and-appendiceal-malignancies/)

## Paper topics

- [Intraperitoneal and Appendiceal Malignancies](https://scholariq.org/topics/intraperitoneal-and-appendiceal-malignancies/)
- [Ovarian cancer diagnosis and treatment](https://scholariq.org/topics/ovarian-cancer-diagnosis-and-treatment/)
- [Pancreatic and Hepatic Oncology Research](https://scholariq.org/topics/pancreatic-and-hepatic-oncology-research/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.