# Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/rare-coding-variants-in-plcg2-abi3-and-trem2-implicate-microglial-mediated/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Rebecca Sims,GERAD/PERADES, CHARGE, ADGC, EADI,Sven J. van der Lee,Adam C. Naj,Céline Bellenguez,Nandini Badarinarayan,Jóhanna Jakobsdóttir,Brian W. Kunkle,Anne Boland,Rachel Raybould,Joshua C Bis,Eden R. Martin,Benjamin Grenier‐Boley,Stefanie Heilmann‐Heimbach,Vincent Chouraki,Amanda Kuzma,Kristel Sleegers,Maria Vronskaya,Agustı́n Ruiz,Robert Graham,Robert Olaso,Per Hoffmann,Megan L. Grove,Badri N. Vardarajan,Mikko Hiltunen,Markus M. Nöthen,Charles C. White,Kara L. Hamilton‐Nelson,Jacques Epelbaum,Wolfgang Maier,Seung-Hoan Choi,Gary W. Beecham,Cécile Dulary,Stefan Herms,Albert V. Smith,Cory C. Funk,Céline Derbois,Andreas J. Forstner,Shahzad Ahmad,Hong‐Dong Li,Delphine Bacq,Denise Harold,Claudia L. Satizábal,Otto Valladares,Alessio Squassina,Rhodri Thomas,Jennifer A. Brody,Liming Qu,Pascual Sánchez‐Juan,Taniesha Morgan,Frank J. Wolters,Yi Zhao,Florentino Sánchez-García,Nicola Denning,Myriam Fornage,John Malamon,María Cándida Déniz Naranjo,Elisa Majounie,Thomas H. Mosley,Beth A. Dombroski,David Wallon,Michelle K. Lupton,Josée Dupuis,Patrice L. Whitehead,Laura Fratiglioni,Christopher Medway,Xueqiu Jian,Shubhabrata Mukherjee,Lina Keller,Kristelle Brown,Honghuang Lin,Laura B. Cantwell,Francesco Panza,Bernadette McGuinness,Sonia Moreno–Grau,Jeremy D. Burgess,Vincenzo Solfrizzi,Petra Proitsi,Hieab H.H. Adams,Mariet Allen,Davide Seripa,Pau Pástor,L. Adrienne Cupples,Nathan D. Price,Didier Hannequin,Ana Frank,Daniel Levy,Paramita Chakrabarty,Paolo Caffarra,Ina Giegling,Alexa Beiser,Vilmantas Giedraitis,Harald Hampel,Melissa E. Garcia,Xue Wang,Lars Lannfelt,Patrizia Mecocci,Gudny Eiriksdottir,Paul K. Crane,Florence Pasquier |
| Citations | 1,115 |
| DOI | 10.1038/ng.3916 |
| Fields | Immunology and Microbiology,Medicine,Neuroscience |
| Open Access | true |
| OA Status | green |
| OA URL | https://pure.amsterdamumc.nl/files/159162870/Rare-coding-variants-in-plcg2-abi3-and-trem2-implicate-microglial-mediated-innate-immunity-in-alzheimers-disease.pdf |
| OpenAlex ID | https://openalex.org/W2592518050 |
| PMID | 28714976 |
| Type | article |
| Year | 2017 |

## Paper authors

- [Laura Fratiglioni](https://scholariq.org/researchers/laura-fratiglioni/)
- [Patrizia Mecocci](https://scholariq.org/researchers/patrizia-mecocci/)
- [Francesco Panza](https://scholariq.org/researchers/francesco-panza/)
- [Bernadette McGuinness](https://scholariq.org/researchers/bernadette-mcguinness/)

## Paper primary topic

- [Neuroinflammation and Neurodegeneration Mechanisms](https://scholariq.org/topics/neuroinflammation-and-neurodegeneration-mechanisms/)

## Paper topics

- [Neuroinflammation and Neurodegeneration Mechanisms](https://scholariq.org/topics/neuroinflammation-and-neurodegeneration-mechanisms/)
- [Alzheimer's disease research and treatments](https://scholariq.org/topics/alzheimer-s-disease-research-and-treatments/)
- [Inflammation biomarkers and pathways](https://scholariq.org/topics/inflammation-biomarkers-and-pathways/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.