# ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/ros-pi3k-akt-and-wnt-catenin-signalings-activate-hif-1-induced-metabolic/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Shuohui Dong,Shuo Liang,Zhiqiang Cheng,Xiang Zhang,Li Luo,Linchuan Li,Wenjie Zhang,Songhan Li,Qian Xu,Mingwei Zhong,Jiankang Zhu,Guangyong Zhang,Sanyuan Hu |
| Citations | 461 |
| DOI | 10.1186/s13046-021-02229-6 |
| Fields | Biochemistry, Genetics and Molecular Biology,Medicine |
| Open Access | true |
| OA Status | gold |
| OA URL | https://jeccr.biomedcentral.com/counter/pdf/10.1186/s13046-021-02229-6 |
| OpenAlex ID | https://openalex.org/W4220817929 |
| PMID | 34998404 |
| Type | article |
| Year | 2022 |

## Paper authors

- [Xiang Zhang](https://scholariq.org/researchers/xiang-zhang/)

## Paper journal

- [Journal of Experimental & Clinical Cancer Research](https://scholariq.org/journals/journal-of-experimental-and-clinical-cancer-research/)

## Paper primary topic

- [Cancer, Hypoxia, and Metabolism](https://scholariq.org/topics/cancer-hypoxia-and-metabolism/)

## Paper topics

- [Cancer, Hypoxia, and Metabolism](https://scholariq.org/topics/cancer-hypoxia-and-metabolism/)
- [Colorectal Cancer Treatments and Studies](https://scholariq.org/topics/colorectal-cancer-treatments-and-studies/)
- [Cancer Cells and Metastasis](https://scholariq.org/topics/cancer-cells-and-metastasis/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.