# Safety, pharmacokinetics, and pharmacodynamics of lumacaftor and ivacaftor combination therapy in children aged 2–5 years with cystic fibrosis homozygous for F508del-CFTR: an open-label phase 3 study

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/safety-pharmacokinetics-and-pharmacodynamics-of-lumacaftor-and-ivacaftor/

## Facts

| Field | Value |
| --- | --- |
| Author Names | John McNamara,Susanna A. McColley,Gautham Marigowda,Fang Liu,Simon Tian,Caroline A. Owen,David Stiles,Chonghua Li,David Waltz,Linda T. Wang,Gregory S. Sawicki |
| Citations | 135 |
| DOI | 10.1016/s2213-2600(18)30460-0 |
| Fields | Health Professions,Immunology and Microbiology,Medicine |
| Open Access | false |
| OA Status | closed |
| OpenAlex ID | https://openalex.org/W2911232211 |
| PMID | 30686767 |
| Type | article |
| Year | 2019 |

## Paper authors

- [Fang Liu](https://scholariq.org/researchers/fang-liu/)

## Paper journal

- [The Lancet Respiratory Medicine](https://scholariq.org/journals/the-lancet-respiratory-medicine/)

## Paper primary topic

- [Cystic Fibrosis Research Advances](https://scholariq.org/topics/cystic-fibrosis-research-advances/)

## Paper topics

- [Cystic Fibrosis Research Advances](https://scholariq.org/topics/cystic-fibrosis-research-advances/)
- [Pediatric health and respiratory diseases](https://scholariq.org/topics/pediatric-health-and-respiratory-diseases/)
- [Immunodeficiency and Autoimmune Disorders](https://scholariq.org/topics/immunodeficiency-and-autoimmune-disorders/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.