# SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/sars-cov-2-spike-protein-impairs-endothelial-function-via-downregulation-of-ace/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Yuyang Lei,Jianyu Zhang,Jianyu Zhang,Cara R. Schiavon,Ming He,Lili Chen,Hui Shen,Yichi Zhang,Qian Yin,Yoshitake Cho,Leonardo R. Andrade,Gerald S. Shadel,Mark Hepokoski,Ting Lei,Hongliang Wang,Jin Zhang,Jin Zhang,Jason X.‐J. Yuan,Atul Malhotra,Uri Manor,Shengpeng Wang,Zu-Yi Yuan,John Y-J. Shyy |
| Citations | 498 |
| DOI | 10.1161/circresaha.121.318902 |
| Fields | Medicine |
| Open Access | true |
| OA Status | green |
| OA URL | https://www.ncbi.nlm.nih.gov/pmc/articles/8091897 |
| OpenAlex ID | https://openalex.org/W3145359886 |
| PMID | 33784827 |
| Type | article |
| Year | 2021 |

## Paper authors

- [Lili Chen](https://scholariq.org/researchers/lili-chen/)

## Paper primary topic

- [COVID-19 Clinical Research Studies](https://scholariq.org/topics/covid-19-clinical-research-studies/)

## Paper topics

- [COVID-19 Clinical Research Studies](https://scholariq.org/topics/covid-19-clinical-research-studies/)
- [Long-Term Effects of COVID-19](https://scholariq.org/topics/long-term-effects-of-covid-19/)
- [SARS-CoV-2 and COVID-19 Research](https://scholariq.org/topics/sars-cov-2-and-covid-19-research/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.