# Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/sin1-phosphorylation-impairs-mtorc2-complex-integrity-and-inhibits-downstream/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Pengda Liu,Wenjian Gan,Hiroyuki Inuzuka,Adam S. Lazorchak,Daming Gao,Omotooke Arojo,Dou Liu,Lixin Wan,Bo Zhai,Yonghao Yu,Min Yuan,Byeong Mo Kim,Shavali Shaik,Suchithra Menon,Steven P. Gygi,Tae Ho Lee,John M. Asara,Brendan D. Manning,John Blenis,Bing Su,Wenyi Wei |
| Citations | 258 |
| DOI | 10.1038/ncb2860 |
| Fields | Biochemistry, Genetics and Molecular Biology,Immunology and Microbiology |
| Open Access | true |
| OA Status | green |
| OA URL | https://ir.ymlib.yonsei.ac.kr/handle/22282913/158412 |
| OpenAlex ID | https://openalex.org/W2113491029 |
| PMID | 24161930 |
| Type | article |
| Year | 2013 |

## Paper authors

- [Bo Zhai](https://scholariq.org/researchers/bo-zhai/)

## Paper primary topic

- [PI3K/AKT/mTOR signaling in cancer](https://scholariq.org/topics/pi3k-akt-mtor-signaling-in-cancer/)

## Paper topics

- [PI3K/AKT/mTOR signaling in cancer](https://scholariq.org/topics/pi3k-akt-mtor-signaling-in-cancer/)
- [Protein Kinase Regulation and GTPase Signaling](https://scholariq.org/topics/protein-kinase-regulation-and-gtpase-signaling/)
- [Mast cells and histamine](https://scholariq.org/topics/mast-cells-and-histamine/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.