# Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/successful-transduction-of-liver-in-hemophilia-by-aav-factor-ix-and-limitations/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Catherine S. Manno,Glenn F. Pierce,Valder R. Arruda,Bertil Glader,Margaret V. Ragni,John E.J. Rasko,Margareth C. Ozelo,Keith Hoots,Philip M. Blatt,Barbara A. Konkle,Michael D. Dake,Robin Kaye,Mahmood Razavi,Albert Zajko,James L. Zehnder,Pradip K. Rustagi,Hiroyuki Nakai,Amy Chew,Debra G. B. Leonard,J Fraser Wright,Ruth Lessard,Jürg M. Sommer,Michael Tigges,Denise E. Sabatino,Alvin Luk,Haiyan Jiang,Federico Mingozzi,Linda Couto,Hildegund C.J. Ertl,Katherine A. High,Mark A. Kay |
| Citations | 2,148 |
| DOI | 10.1038/nm1358 |
| Fields | Biochemistry, Genetics and Molecular Biology,Medicine |
| Open Access | false |
| OA Status | closed |
| OpenAlex ID | https://openalex.org/W1976329054 |
| PMID | 16474400 |
| Type | article |
| Year | 2006 |

## Paper authors

- [Michael D. Dake](https://scholariq.org/researchers/michael-d-dake/)

## Paper journal

- [Nature Medicine](https://scholariq.org/journals/nature-medicine/)

## Paper primary topic

- [Virus-based gene therapy research](https://scholariq.org/topics/virus-based-gene-therapy-research/)

## Paper topics

- [Virus-based gene therapy research](https://scholariq.org/topics/virus-based-gene-therapy-research/)
- [RNA Interference and Gene Delivery](https://scholariq.org/topics/rna-interference-and-gene-delivery/)
- [CAR-T cell therapy research](https://scholariq.org/topics/car-t-cell-therapy-research/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.