# Suitability Of Nitisinone In Alkaptonuria 1 (SONIA 1): an international, multicentre, randomised, open-label, no-treatment controlled, parallel-group, dose-response study to investigate the effect of once daily nitisinone on 24-h urinary homogentisic acid excretion in patients with alkaptonuria after 4 weeks of treatment

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/suitability-of-nitisinone-in-alkaptonuria-1-sonia-1-an-international-multicentre/

## Facts

| Field | Value |
| --- | --- |
| Author Names | L. Ranganath,Anna M. Milan,Andrew T. Hughes,John Dutton,Richard J. Fitzgerald,Michael Briggs,Helen Bygott,Eftychia Eirini Psarelli,Trevor F. Cox,James A. Gallagher,Jonathan C. Jarvis,Christa van Kan,Anthony K Hall,Dinny Laan,Birgitta Olsson,Johan Szamosi,Mattias Rudebeck,Torbjörn Kullenberg,Arvid Cronlund,Lennart Svensson,Carin Junestrand,Hana Ayoob,Oliver Timmis,Nicolas Sireau,Kim‐Hanh Le Quan Sang,Federica Genovese,Daniela Braconi,Annalisa Santucci,Martina Nemethova,Andrea Zaťková,Judith C. McCaffrey,Peter Christensen,Gordon Ross,Richard Imrich,Jozef Rovenský |
| Citations | 159 |
| DOI | 10.1136/annrheumdis-2014-206033 |
| Fields | Biochemistry, Genetics and Molecular Biology,Pharmacology, Toxicology and Pharmaceutics |
| Open Access | true |
| OA Status | green |
| OA URL | https://researchonline.ljmu.ac.uk/id/eprint/2261/3/SONIA1%20Final%20Manuscript.pdf |
| OpenAlex ID | https://openalex.org/W2154418484 |
| PMID | 25475116 |
| Type | article |
| Year | 2014 |

## Paper authors

- [Federica Genovese](https://scholariq.org/researchers/federica-genovese/)

## Paper journal

- [Annals of the Rheumatic Diseases](https://scholariq.org/journals/annals-of-the-rheumatic-diseases/)

## Paper primary topic

- [Metabolism and Genetic Disorders](https://scholariq.org/topics/metabolism-and-genetic-disorders/)

## Paper topics

- [Metabolism and Genetic Disorders](https://scholariq.org/topics/metabolism-and-genetic-disorders/)
- [Blood disorders and treatments](https://scholariq.org/topics/blood-disorders-and-treatments/)
- [Pharmacogenetics and Drug Metabolism](https://scholariq.org/topics/pharmacogenetics-and-drug-metabolism/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.