# Switching to riociguat versus maintenance therapy with phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension (REPLACE): a multicentre, open-label, randomised controlled trial

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/switching-to-riociguat-versus-maintenance-therapy-with-phosphodiesterase-5/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Marius M. Hoeper,Hikmet Al‐Hiti,Raymond L. Benza,Sung‐A Chang,Paul A. Corris,J. Simon R. Gibbs,Ekkehard Grünig,Pavel Jansa,James R. Klinger,David Langleben,Vallerie V. McLaughlin,G. Meyer,Jaquelina Sonoe Ota Arakaki,Andrew J. Peacock,Tomás Pulido,Stephan Rosenkranz,Carmine Dario Vizza,Anton Vonk Noordegraaf,R.J. White,Mikyung Chang,Frank Kleinjung,Christian Meier,Karen Paraschin,Hossein Ardeschir Ghofrani,Gérald Simonneau,Horst Olschewski,Marion Delcroix,Marina Andrade‐Lima,R de Amorim Corrêac,F Figueiredo Campos,Jaquelina O. Arakaki,G. Meyer,Rogério Souza,David Langleben,Hikmet Al‐Hiti,Pavel Jansa,Søren Mellemkjær,Fabrice Bauer,David Montani,Gérald Simonneau,Daniel Drömann,H-A Ghofrani,Ekkehard Grünig,Michael Halank,Matthias Held,Marius M. Hoeper,Hans Klose,Nikolaus Kneidinger,Hanno Leuchte,Christian Opitz,Stephan Rosenkranz,Heinrike Wilkens,Hubert Wirtz,Haralampos Karvounis,Georgia Pitsiou,Stylianos E. Orfanos,Michael D’Alto,Stefano Ghio,CD Vizza,Patrizio Vitulo,T. Nakayama,Hisataka Maki,Shunsuke Tatebe,Manuel Ibarra,Tomás Pulido,Arie P.J. van Dijk,Anton Vonk Noordegraaf,Tomasz Roleder,G. Castro,MJ Loureiro,Susana Robalo-Martins,Joan Albert Barberà,M Lázaro,GM Perez-Penate,Antonio Román,C-C Cheng,C-H. Hsu,H-H Hsu,Erhan Atahan,N Mogulkoc Bishop,NG Okumus,Zeynep Pınar Önen,Chang Hj,S-A Chang,Jin Sun Lee,H-K Kim,JG Coghlan,PA Corris,Colin Church,Robin Condliffe,J. Simon R. Gibbs,AJ Peacock,Stephen J. Wort,Roblee P. Allen,Samuel A. Allen,Rana Awdish,RL Benza,Shilpa A. DeSouza,Jeremy Feldman,Shilpa Johri |
| Citations | 161 |
| DOI | 10.1016/s2213-2600(20)30532-4 |
| Fields | Biochemistry, Genetics and Molecular Biology,Medicine |
| Open Access | true |
| OA Status | green |
| OA URL | https://pure.amsterdamumc.nl/ws/files/212000470/Switching-to-riociguat-versus-maintenance-therapy-with-phosphodiesterase-5-inhibitors-in-patients-with-pulmonary-arteria.pdf |
| OpenAlex ID | https://openalex.org/W3138574248 |
| PMID | 33773120 |
| Type | article |
| Year | 2021 |

## Paper authors

- [Frank Kleinjung](https://scholariq.org/researchers/frank-kleinjung/)

## Paper journal

- [The Lancet Respiratory Medicine](https://scholariq.org/journals/the-lancet-respiratory-medicine/)

## Paper primary topic

- [Pulmonary Hypertension Research and Treatments](https://scholariq.org/topics/pulmonary-hypertension-research-and-treatments/)

## Paper topics

- [Pulmonary Hypertension Research and Treatments](https://scholariq.org/topics/pulmonary-hypertension-research-and-treatments/)
- [Phosphodiesterase function and regulation](https://scholariq.org/topics/phosphodiesterase-function-and-regulation/)
- [Heart Failure Treatment and Management](https://scholariq.org/topics/heart-failure-treatment-and-management/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.