# Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-<i>N</i>2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-<i>N</i>4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/synthesis-structure-activity-relationships-and-in-vivo-efficacy-of-the-novel/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Thomas H. Marsilje,Wei Pei,Bei Chen,Wenshuo Lu,Tetsuo Uno,Yunho Jin,Tao Jiang,Sung Joon Kim,Nanxin Li,Markus Warmuth,Yelena Sarkisova,Frank F. Sun,Auzon Steffy,AnneMarie Culazzo Pferdekamper,Allen G. Li,Sean B. Joseph,Young Ho Kim,Bo Liu,Tove Tuntland,Xiaoming Cui,Nathanael S. Gray,Ruo W. Steensma,Yongqin Wan,Jiqing Jiang,Greg Chopiuk,Jie Li,W. Perry Gordon,Wendy Richmond,Kevin C. Johnson,Jonathan Chang,Todd Groessl,You-Qun He,Andrew Phimister,J. Alex Aycinena,Christian C. Lee,Badry Bursulaya,Donald S. Karanewsky,H. Martin Seidel,Jennifer L. Harris,Pierre‐Yves Michellys |
| Citations | 412 |
| DOI | 10.1021/jm400402q |
| Fields | Biochemistry, Genetics and Molecular Biology,Chemistry,Medicine |
| Open Access | true |
| OA Status | green |
| OA URL | https://doi.org/10.7270/q2g1627j |
| OpenAlex ID | https://openalex.org/W2080992857 |
| PMID | 23742252 |
| Type | article |
| Year | 2013 |

## Paper authors

- [Jie Li](https://scholariq.org/researchers/jie-li-2/)

## Paper primary topic

- [Cancer therapeutics and mechanisms](https://scholariq.org/topics/cancer-therapeutics-and-mechanisms/)

## Paper topics

- [Cancer therapeutics and mechanisms](https://scholariq.org/topics/cancer-therapeutics-and-mechanisms/)
- [Lung Cancer Treatments and Mutations](https://scholariq.org/topics/lung-cancer-treatments-and-mutations/)
- [Quinazolinone synthesis and applications](https://scholariq.org/topics/quinazolinone-synthesis-and-applications/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.