# The PREMIER study: A multicenter, randomized, double‐blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment

**Type:** Papers  
**Canonical URL:** https://scholariq.org/papers/the-premier-study-a-multicenter-randomized-double-blind-clinical-trial-of/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Ferdinand C. Breedveld,Michael H. Weisman,Arthur F. Kavanaugh,Stanley Cohen,Karel Pavelká,Ronald van Vollenhoven,John T. Sharp,John L. Perez,G Spencer-Green |
| Citations | 1,788 |
| DOI | 10.1002/art.21519 |
| Fields | Medicine |
| Open Access | false |
| OA Status | closed |
| OpenAlex ID | https://openalex.org/W1996389186 |
| PMID | 16385520 |
| Type | article |
| Year | 2005 |

## Paper authors

- [Ronald van Vollenhoven](https://scholariq.org/researchers/ronald-van-vollenhoven/)

## Paper primary topic

- [Rheumatoid Arthritis Research and Therapies](https://scholariq.org/topics/rheumatoid-arthritis-research-and-therapies/)

## Paper topics

- [Rheumatoid Arthritis Research and Therapies](https://scholariq.org/topics/rheumatoid-arthritis-research-and-therapies/)
- [Spondyloarthritis Studies and Treatments](https://scholariq.org/topics/spondyloarthritis-studies-and-treatments/)
- [Autoimmune and Inflammatory Disorders Research](https://scholariq.org/topics/autoimmune-and-inflammatory-disorders-research/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.