# Barrier Structure and Function Studies

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/barrier-structure-and-function-studies/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the structure, function, and dysfunction of the blood-brain barrier, as well as the interactions between astrocytes, endothelial cells, and pericytes in the neurovascular unit. It covers topics such as tight junctions, CNS drug delivery, neurological diseases, and the role of various cell types in maintaining vascular homeostasis. |
| Domain | Life Sciences |
| Field | Neuroscience |
| OpenAlex ID | t11872 |
| Works | 150 |

## Topic papers all

Showing 15 of 150.

- [Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target](https://scholariq.org/papers/selecting-therapeutic-targets-in-inflammatory-bowel-disease-stride-determining/)
- [Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction](https://scholariq.org/papers/blood-brain-barrier-breakdown-is-an-early-biomarker-of-human-cognitive/)
- [Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease†](https://scholariq.org/papers/increased-intestinal-permeability-and-tight-junction-alterations-in-nonalcoholic/)
- [The movers and shapers in immune privilege of the CNS](https://scholariq.org/papers/the-movers-and-shapers-in-immune-privilege-of-the-cns/)
- [Tight junction defects in patients with atopic dermatitis](https://scholariq.org/papers/tight-junction-defects-in-patients-with-atopic-dermatitis/)
- [A gut-vascular barrier controls the systemic dissemination of bacteria](https://scholariq.org/papers/a-gut-vascular-barrier-controls-the-systemic-dissemination-of-bacteria/)
- [The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease](https://scholariq.org/papers/the-contribution-of-nod2-gene-mutations-to-the-risk-and-site-of-disease-in/)
- [Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism](https://scholariq.org/papers/psychological-stress-and-corticotropin-releasing-hormone-increase-intestinal/)
- [Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor–Dependent Repression of Claudin-2](https://scholariq.org/papers/microbial-derived-butyrate-promotes-epithelial-barrier-function-through-il-10/)
- [Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s disease mouse models](https://scholariq.org/papers/neutrophil-adhesion-in-brain-capillaries-reduces-cortical-blood-flow-and-impairs/)
- [Mutations in the Tight-Junction Gene Claudin 19 (CLDN19) Are Associated with Renal Magnesium Wasting, Renal Failure, and Severe Ocular Involvement](https://scholariq.org/papers/mutations-in-the-tight-junction-gene-claudin-19-cldn19-are-associated-with-renal/)
- [Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators](https://scholariq.org/papers/impaired-intestinal-barrier-integrity-in-the-colon-of-patients-with-irritable/)
- [Vascular Endothelial Growth Factor/Vascular Permeability Factor Enhances Vascular Permeability Via Nitric Oxide and Prostacyclin](https://scholariq.org/papers/vascular-endothelial-growth-factor-vascular-permeability-factor-enhances/)
- [Protective Role of Reactive Astrocytes in Brain Ischemia](https://scholariq.org/papers/protective-role-of-reactive-astrocytes-in-brain-ischemia/)
- [Brain barrier systems: a new frontier in metal neurotoxicological research](https://scholariq.org/papers/brain-barrier-systems-a-new-frontier-in-metal-neurotoxicological-research/)

## Topic primary papers

Showing 15 of 60.

- [Tight junction defects in patients with atopic dermatitis](https://scholariq.org/papers/tight-junction-defects-in-patients-with-atopic-dermatitis/)
- [A gut-vascular barrier controls the systemic dissemination of bacteria](https://scholariq.org/papers/a-gut-vascular-barrier-controls-the-systemic-dissemination-of-bacteria/)
- [Mutations in the Tight-Junction Gene Claudin 19 (CLDN19) Are Associated with Renal Magnesium Wasting, Renal Failure, and Severe Ocular Involvement](https://scholariq.org/papers/mutations-in-the-tight-junction-gene-claudin-19-cldn19-are-associated-with-renal/)
- [Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators](https://scholariq.org/papers/impaired-intestinal-barrier-integrity-in-the-colon-of-patients-with-irritable/)
- [Loss of the Tight Junction Protein ZO-1 in Dextran Sulfate Sodium Induced Colitis](https://scholariq.org/papers/loss-of-the-tight-junction-protein-zo-1-in-dextran-sulfate-sodium-induced/)
- [Role of Urea in Intestinal Barrier Dysfunction and Disruption of Epithelial Tight Junction in Chronic Kidney Disease](https://scholariq.org/papers/role-of-urea-in-intestinal-barrier-dysfunction-and-disruption-of-epithelial/)
- [RETRACTED ARTICLE: Pericyte degeneration causes white matter dysfunction in the mouse central nervous system](https://scholariq.org/papers/retracted-article-pericyte-degeneration-causes-white-matter-dysfunction-in-the/)
- [A single-cell atlas of the normal and malformed human brain vasculature](https://scholariq.org/papers/a-single-cell-atlas-of-the-normal-and-malformed-human-brain-vasculature/)
- [IL1B Increases Intestinal Tight Junction Permeability by Up-regulation of MIR200C-3p, Which Degrades Occludin mRNA](https://scholariq.org/papers/il1b-increases-intestinal-tight-junction-permeability-by-up-regulation-of/)
- [Genetic and Transcriptomic Bases of Intestinal Epithelial Barrier Dysfunction in Inflammatory Bowel Disease](https://scholariq.org/papers/genetic-and-transcriptomic-bases-of-intestinal-epithelial-barrier-dysfunction-in/)
- [Blood–brain barrier models and their relevance for a successful development of CNS drug delivery systems: A review](https://scholariq.org/papers/blood-brain-barrier-models-and-their-relevance-for-a-successful-development-of/)
- [Gastrointestinal mucosal barrier function and diseases](https://scholariq.org/papers/gastrointestinal-mucosal-barrier-function-and-diseases/)
- [Indole-3-propionic Acid Improved the Intestinal Barrier by Enhancing Epithelial Barrier and Mucus Barrier](https://scholariq.org/papers/indole-3-propionic-acid-improved-the-intestinal-barrier-by-enhancing-epithelial/)
- [HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity](https://scholariq.org/papers/hif-dependent-regulation-of-claudin-1-is-central-to-intestinal-epithelial-tight/)
- [Permeability of Endothelial and Astrocyte Cocultures: In Vitro Blood–Brain Barrier Models for Drug Delivery Studies](https://scholariq.org/papers/permeability-of-endothelial-and-astrocyte-cocultures-in-vitro-blood-brain/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.