# Bioactive Compounds and Antitumor Agents **Type:** Topics **Canonical URL:** https://scholariq.org/topics/bioactive-compounds-and-antitumor-agents/ ## Facts | Field | Value | | --- | --- | | Description | This cluster of papers explores the role of quinones in toxicology and pharmacology, focusing on their cytotoxic effects, NAD(P)H:Quinone Oxidoreductase activity, apoptosis induction, and potential as anticancer and antimicrobial agents. The papers cover a wide range of topics including cellular pharmacology studies, mechanisms of cytotoxic action, pharmacological properties, and the synthesis and evaluation of quinone derivatives. | | Domain | Life Sciences | | Field | Pharmacology, Toxicology and Pharmaceutics | | OpenAlex ID | t12356 | | Works | 58 | ## Topic papers all Showing 15 of 58. - [Drugging Topoisomerases: Lessons and Challenges](https://scholariq.org/papers/drugging-topoisomerases-lessons-and-challenges/) - [Hoe 140 a new potent and long acting bradykinin‐antagonist:in vivostudies](https://scholariq.org/papers/hoe-140-a-new-potent-and-long-acting-bradykinin-antagonist-i-in-vivo-i-studies/) - [Phase III Trial of Four Cisplatin-Containing Doublet Combinations in Stage IVB, Recurrent, or Persistent Cervical Carcinoma: A Gynecologic Oncology Group Study](https://scholariq.org/papers/phase-iii-trial-of-four-cisplatin-containing-doublet-combinations-in-stage-ivb/) - [Increased Vascular Smooth Muscle Contractility in TRPC6−/− Mice](https://scholariq.org/papers/increased-vascular-smooth-muscle-contractility-in-i-trpc6-i-sup-sup-sup-sup-sup/) - [Free radical formation by antitumor quinones](https://scholariq.org/papers/free-radical-formation-by-antitumor-quinones/) - [In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway](https://scholariq.org/papers/in-vitro-and-in-vivo-induction-of-apoptosis-by-capsaicin-in-pancreatic-cancer/) - [The Role of Curcumin in Cancer Treatment](https://scholariq.org/papers/the-role-of-curcumin-in-cancer-treatment/) - [Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor](https://scholariq.org/papers/allosteric-inhibition-of-shp2-identification-of-a-potent-selective-and-orally/) - [Black cumin (Nigella sativa) and its constituent (thymoquinone): a review on antimicrobial effects.](https://scholariq.org/papers/black-cumin-nigella-sativa-and-its-constituent-thymoquinone-a-review-on/) - [Redox regulation of cell migration and adhesion](https://scholariq.org/papers/redox-regulation-of-cell-migration-and-adhesion/) - [Molecular Mechanisms of c-Jun N-terminal Kinase-mediated Apoptosis Induced by Anticarcinogenic Isothiocyanates](https://scholariq.org/papers/molecular-mechanisms-of-c-jun-n-terminal-kinase-mediated-apoptosis-induced-by/) - [Structure–activity relationships for inhibition of human 5α-reductases by polyphenols](https://scholariq.org/papers/structure-activity-relationships-for-inhibition-of-human-5-reductases-by/) - [Plumbagin (5-Hydroxy-2-methyl-1,4-naphthoquinone) Induces Apoptosis and Cell Cycle Arrest in A549 Cells through p53 Accumulation via c-Jun NH2-Terminal Kinase-Mediated Phosphorylation at Serine 15 in Vitro and in Vivo](https://scholariq.org/papers/plumbagin-5-hydroxy-2-methyl-1-4-naphthoquinone-induces-apoptosis-and-cell-cycle/) - [Bioavailability of Sulforaphane from Two Broccoli Sprout Beverages: Results of a Short-term, Cross-over Clinical Trial in Qidong, China](https://scholariq.org/papers/bioavailability-of-sulforaphane-from-two-broccoli-sprout-beverages-results-of-a/) - [Viscum album \[L.\] extract therapy in patients with locally advanced or metastatic pancreatic cancer: A randomised clinical trial on overall survival](https://scholariq.org/papers/viscum-album-l-extract-therapy-in-patients-with-locally-advanced-or-metastatic/) ## Topic primary papers - [Free radical formation by antitumor quinones](https://scholariq.org/papers/free-radical-formation-by-antitumor-quinones/) - [Plumbagin (5-Hydroxy-2-methyl-1,4-naphthoquinone) Induces Apoptosis and Cell Cycle Arrest in A549 Cells through p53 Accumulation via c-Jun NH2-Terminal Kinase-Mediated Phosphorylation at Serine 15 in Vitro and in Vivo](https://scholariq.org/papers/plumbagin-5-hydroxy-2-methyl-1-4-naphthoquinone-induces-apoptosis-and-cell-cycle/) - [Pharmacological activation of NQO1 increases NAD+ levels and attenuates cisplatin-mediated acute kidney injury in mice](https://scholariq.org/papers/pharmacological-activation-of-nqo1-increases-nad-levels-and-attenuates-cisplatin/) - [Review of Shikonin and Derivatives: Isolation, Chemistry, Biosynthesis, Pharmacology and Toxicology](https://scholariq.org/papers/review-of-shikonin-and-derivatives-isolation-chemistry-biosynthesis-pharmacology/) - [Induction of Apoptosis by Shikonin through Coordinative Modulation of the Bcl-2 Family, p27, and p53, Release of Cytochrome c, and Sequential Activation of Caspases in Human Colorectal Carcinoma Cells](https://scholariq.org/papers/induction-of-apoptosis-by-shikonin-through-coordinative-modulation-of-the-bcl-2/) - [Anti-inflammatory effect of Apo-9′-fucoxanthinone via inhibition of MAPKs and NF-kB signaling pathway in LPS-stimulated RAW 264.7 macrophages and zebrafish model](https://scholariq.org/papers/anti-inflammatory-effect-of-apo-9-fucoxanthinone-via-inhibition-of-mapks-and-nf/) - [The Coffee Constituent Chlorogenic Acid Induces Cellular DNA Damage and Formation of Topoisomerase I– and II–DNA Complexes in Cells](https://scholariq.org/papers/the-coffee-constituent-chlorogenic-acid-induces-cellular-dna-damage-and/) - [Plumbagin reverses proliferation and resistance to apoptosis in experimental PAH](https://scholariq.org/papers/plumbagin-reverses-proliferation-and-resistance-to-apoptosis-in-experimental-pah/) - [Insights into the redox cycle of human quinone reductase 2](https://scholariq.org/papers/insights-into-the-redox-cycle-of-human-quinone-reductase-2/) - [In cellulo monitoring of quinone reductase activity and reactive oxygen species production during the redox cycling of 1,2 and 1,4 quinones](https://scholariq.org/papers/in-cellulo-monitoring-of-quinone-reductase-activity-and-reactive-oxygen-species/) - [Oxidative stress and neurodegeneration: The possible contribution of quinone reductase 2](https://scholariq.org/papers/oxidative-stress-and-neurodegeneration-the-possible-contribution-of-quinone/) - [Sedative-hypnotic effect and in silico study of dinaphthodiospyrols isolated from Diospyros lotus Linn](https://scholariq.org/papers/sedative-hypnotic-effect-and-in-silico-study-of-dinaphthodiospyrols-isolated/) - [Shikonin mitigates diabetic testicular dysfunction by improving oxidative, apoptotic, and metabolic functions in rats](https://scholariq.org/papers/shikonin-mitigates-diabetic-testicular-dysfunction-by-improving-oxidative/) --- Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.