# Bone Metabolism and Diseases

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/bone-metabolism-and-diseases/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers explores the molecular mechanisms underlying osteoclast differentiation, bone resorption, and the regulation of bone homeostasis. It delves into the signaling pathways, transcription factors, and cytokines involved in osteoclast and osteoblast differentiation, as well as the interplay between the immune system and bone metabolism. Additionally, it investigates the impact of oxidative stress and inflammatory cytokines on bone remodeling. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t11219 |
| Works | 264 |

## Topic papers all

Showing 15 of 264.

- [Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development](https://scholariq.org/papers/cbfa1-a-candidate-gene-for-cleidocranial-dysplasia-syndrome-is-essential-for/)
- [Postmenopausal Osteoporosis](https://scholariq.org/papers/postmenopausal-osteoporosis/)
- [Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture](https://scholariq.org/papers/genome-wide-meta-analysis-identifies-56-bone-mineral-density-loci-and-reveals-14/)
- [Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells.](https://scholariq.org/papers/origin-of-osteoclasts-mature-monocytes-and-macrophages-are-capable-of/)
- [Markers of bone resorption predict hip fracture in elderly women: The EPIDOS prospective study](https://scholariq.org/papers/markers-of-bone-resorption-predict-hip-fracture-in-elderly-women-the-epidos/)
- [Loss of the ClC-7 Chloride Channel Leads to Osteopetrosis in Mice and Man](https://scholariq.org/papers/loss-of-the-clc-7-chloride-channel-leads-to-osteopetrosis-in-mice-and-man/)
- [Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society Clinical Practice Guideline](https://scholariq.org/papers/pharmacological-management-of-osteoporosis-in-postmenopausal-women-an-endocrine/)
- [X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-κB signaling](https://scholariq.org/papers/x-linked-anhidrotic-ectodermal-dysplasia-with-immunodeficiency-is-caused-by/)
- [Intermittent Etidronate Therapy to Prevent Corticosteroid-Induced Osteoporosis](https://scholariq.org/papers/intermittent-etidronate-therapy-to-prevent-corticosteroid-induced-osteoporosis/)
- [Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis](https://scholariq.org/papers/defects-in-tcirg1-subunit-of-the-vacuolar-proton-pump-are-responsible-for-a/)
- [Targeting the TGFβ pathway for cancer therapy](https://scholariq.org/papers/targeting-the-tgf-pathway-for-cancer-therapy/)
- [Matrix Metalloproteinase 9 and Vascular Endothelial Growth Factor Are Essential for Osteoclast Recruitment into Developing Long Bones](https://scholariq.org/papers/matrix-metalloproteinase-9-and-vascular-endothelial-growth-factor-are-essential/)
- [Biological Functions of miR-29b Contribute to Positive Regulation of Osteoblast Differentiation](https://scholariq.org/papers/biological-functions-of-mir-29b-contribute-to-positive-regulation-of-osteoblast/)
- [2017 American College of Rheumatology Guideline for the Prevention and Treatment of Glucocorticoid‐Induced Osteoporosis](https://scholariq.org/papers/2017-american-college-of-rheumatology-guideline-for-the-prevention-and-treatment/)
- [Osteopetrosis: genetics, treatment and new insights into osteoclast function](https://scholariq.org/papers/osteopetrosis-genetics-treatment-and-new-insights-into-osteoclast-function/)

## Topic primary papers

Showing 15 of 94.

- [Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development](https://scholariq.org/papers/cbfa1-a-candidate-gene-for-cleidocranial-dysplasia-syndrome-is-essential-for/)
- [Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells.](https://scholariq.org/papers/origin-of-osteoclasts-mature-monocytes-and-macrophages-are-capable-of/)
- [Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis](https://scholariq.org/papers/defects-in-tcirg1-subunit-of-the-vacuolar-proton-pump-are-responsible-for-a/)
- [Osteopetrosis: genetics, treatment and new insights into osteoclast function](https://scholariq.org/papers/osteopetrosis-genetics-treatment-and-new-insights-into-osteoclast-function/)
- [Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression](https://scholariq.org/papers/runx2-control-of-organization-assembly-and-activity-of-the-regulatory-machinery/)
- [Protein Expression and Functional Difference of Membrane-Bound and Soluble Receptor Activator of NF-κB Ligand: Modulation of the Expression by Osteotropic Factors and Cytokines](https://scholariq.org/papers/protein-expression-and-functional-difference-of-membrane-bound-and-soluble/)
- [Osteopetrosis](https://scholariq.org/papers/osteopetrosis/)
- [Networks and hubs for the transcriptional control of osteoblastogenesis](https://scholariq.org/papers/networks-and-hubs-for-the-transcriptional-control-of-osteoblastogenesis/)
- [Essential Role of p38 Mitogen-activated Protein Kinase in Cathepsin K Gene Expression during Osteoclastogenesis through Association of NFATc1 and PU.1](https://scholariq.org/papers/essential-role-of-p38-mitogen-activated-protein-kinase-in-cathepsin-k-gene/)
- [Regulatory Controls for Osteoblast Growth and Differentiation: Role of Runx/Cbfa/AML Factors](https://scholariq.org/papers/regulatory-controls-for-osteoblast-growth-and-differentiation-role-of-runx-cbfa/)
- [The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice](https://scholariq.org/papers/the-p38-mapk-pathway-is-essential-for-skeletogenesis-and-bone-homeostasis-in/)
- [Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL](https://scholariq.org/papers/osteoclast-poor-human-osteopetrosis-due-to-mutations-in-the-gene-encoding-rankl/)
- [Osteoblasts and Osteoclasts in Bone Remodeling and Inflammation](https://scholariq.org/papers/osteoblasts-and-osteoclasts-in-bone-remodeling-and-inflammation/)
- [PTH Differentially Regulates Expression of RANKL and OPG](https://scholariq.org/papers/pth-differentially-regulates-expression-of-rankl-and-opg/)
- [Macrophage Polarization and Osteoporosis: A Review](https://scholariq.org/papers/macrophage-polarization-and-osteoporosis-a-review/)

---
Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.