# Brain Metastases and Treatment

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/brain-metastases-and-treatment/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the management of brain metastases in cancer patients, including the use of radiosurgery and whole-brain radiation therapy, the impact on cognitive function, prognostic assessment, blood-brain barrier permeability, and specific considerations for HER2-positive breast cancer. It also explores the role of immunotherapy, the effects on neurocognitive function, and the challenges associated with leptomeningeal metastasis. |
| Domain | Health Sciences |
| Field | Medicine |
| OpenAlex ID | t11600 |
| Works | 218 |

## Topic papers all

Showing 15 of 218.

- [A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma](https://scholariq.org/papers/a-randomized-trial-of-bevacizumab-for-newly-diagnosed-glioblastoma/)
- [Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial](https://scholariq.org/papers/whole-brain-radiation-therapy-with-or-without-stereotactic-radiosurgery-boost/)
- [A Perivascular Niche for Brain Tumor Stem Cells](https://scholariq.org/papers/a-perivascular-niche-for-brain-tumor-stem-cells/)
- [Effect of Radiosurgery Alone vs Radiosurgery With Whole Brain Radiation Therapy on Cognitive Function in Patients With 1 to 3 Brain Metastases](https://scholariq.org/papers/effect-of-radiosurgery-alone-vs-radiosurgery-with-whole-brain-radiation-therapy/)
- [Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer](https://scholariq.org/papers/sacituzumab-govitecan-in-metastatic-triple-negative-breast-cancer/)
- [Dose-Dense Temozolomide for Newly Diagnosed Glioblastoma: A Randomized Phase III Clinical Trial](https://scholariq.org/papers/dose-dense-temozolomide-for-newly-diagnosed-glioblastoma-a-randomized-phase-iii/)
- [A New Prognostic Index and Comparison to Three Other Indices for Patients With Brain Metastases: An Analysis of 1,960 Patients in the RTOG Database](https://scholariq.org/papers/a-new-prognostic-index-and-comparison-to-three-other-indices-for-patients-with/)
- [Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial](https://scholariq.org/papers/long-term-efficacy-of-early-versus-delayed-radiotherapy-for-low-grade/)
- [Combination nivolumab and ipilimumab or nivolumab alone in melanoma brain metastases: a multicentre randomised phase 2 study](https://scholariq.org/papers/combination-nivolumab-and-ipilimumab-or-nivolumab-alone-in-melanoma-brain/)
- [Metastatic sites and survival in lung cancer](https://scholariq.org/papers/metastatic-sites-and-survival-in-lung-cancer/)
- [Abbreviated Course of Radiation Therapy in Older Patients With Glioblastoma Multiforme: A Prospective Randomized Clinical Trial](https://scholariq.org/papers/abbreviated-course-of-radiation-therapy-in-older-patients-with-glioblastoma/)
- [Promising Survival for Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Concomitant Radiation Plus Temozolomide Followed by Adjuvant Temozolomide](https://scholariq.org/papers/promising-survival-for-patients-with-newly-diagnosed-glioblastoma-multiforme/)
- [Independent association of extent of resection with survival in patients with malignant brain astrocytoma](https://scholariq.org/papers/independent-association-of-extent-of-resection-with-survival-in-patients-with/)
- [Bevacizumab for recurrent malignant gliomas](https://scholariq.org/papers/bevacizumab-for-recurrent-malignant-gliomas/)
- [Immunotherapy response assessment in neuro-oncology: a report of the RANO working group](https://scholariq.org/papers/immunotherapy-response-assessment-in-neuro-oncology-a-report-of-the-rano-working/)

## Topic primary papers

Showing 15 of 65.

- [Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial](https://scholariq.org/papers/whole-brain-radiation-therapy-with-or-without-stereotactic-radiosurgery-boost/)
- [Effect of Radiosurgery Alone vs Radiosurgery With Whole Brain Radiation Therapy on Cognitive Function in Patients With 1 to 3 Brain Metastases](https://scholariq.org/papers/effect-of-radiosurgery-alone-vs-radiosurgery-with-whole-brain-radiation-therapy/)
- [A New Prognostic Index and Comparison to Three Other Indices for Patients With Brain Metastases: An Analysis of 1,960 Patients in the RTOG Database](https://scholariq.org/papers/a-new-prognostic-index-and-comparison-to-three-other-indices-for-patients-with/)
- [Combination nivolumab and ipilimumab or nivolumab alone in melanoma brain metastases: a multicentre randomised phase 2 study](https://scholariq.org/papers/combination-nivolumab-and-ipilimumab-or-nivolumab-alone-in-melanoma-brain/)
- [Intracranial Efficacy and Survival With Tucatinib Plus Trastuzumab and Capecitabine for Previously Treated HER2-Positive Breast Cancer With Brain Metastases in the HER2CLIMB Trial](https://scholariq.org/papers/intracranial-efficacy-and-survival-with-tucatinib-plus-trastuzumab-and/)
- [The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline](https://scholariq.org/papers/the-role-of-stereotactic-radiosurgery-in-the-management-of-patients-with-newly/)
- [Management of Brain Metastases in Tyrosine Kinase Inhibitor–Naïve Epidermal Growth Factor Receptor–Mutant Non–Small-Cell Lung Cancer: A Retrospective Multi-Institutional Analysis](https://scholariq.org/papers/management-of-brain-metastases-in-tyrosine-kinase-inhibitor-naive-epidermal/)
- [The role of surgical resection in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline](https://scholariq.org/papers/the-role-of-surgical-resection-in-the-management-of-newly-diagnosed-brain/)
- [The role of steroids in the management of brain metastases: a systematic review and evidence-based clinical practice guideline](https://scholariq.org/papers/the-role-of-steroids-in-the-management-of-brain-metastases-a-systematic-review/)
- [IMpower150 Final Exploratory Analyses for Atezolizumab Plus Bevacizumab and Chemotherapy in Key NSCLC Patient Subgroups With EGFR Mutations or Metastases in the Liver or Brain](https://scholariq.org/papers/impower150-final-exploratory-analyses-for-atezolizumab-plus-bevacizumab-and/)
- [The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline](https://scholariq.org/papers/the-role-of-whole-brain-radiation-therapy-in-the-management-of-newly-diagnosed/)
- [Radiation induced CNS toxicity – molecular and cellular mechanisms](https://scholariq.org/papers/radiation-induced-cns-toxicity-molecular-and-cellular-mechanisms/)
- [Whole-Brain Radiotherapy for Brain Metastases: Evolution or Revolution?](https://scholariq.org/papers/whole-brain-radiotherapy-for-brain-metastases-evolution-or-revolution/)
- [Outcome of Patients with Non–Small Cell Lung Cancer and Brain Metastases Treated with Checkpoint Inhibitors](https://scholariq.org/papers/outcome-of-patients-with-non-small-cell-lung-cancer-and-brain-metastases-treated/)
- [Triple-negative and HER2-overexpressing breast cancers exhibit an elevated risk and an earlier occurrence of cerebral metastases](https://scholariq.org/papers/triple-negative-and-her2-overexpressing-breast-cancers-exhibit-an-elevated-risk/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.