# Calcium signaling and nucleotide metabolism

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/calcium-signaling-and-nucleotide-metabolism/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers explores the evolution, function, and dysregulation of lysosomal calcium signaling, focusing on the role of two-pore channels, NAADP, TRPML1, and cyclic ADP-ribose in intracellular calcium release and endolysosomal trafficking. It also investigates the implications of these mechanisms in diseases such as mucolipidosis type IV and lysosomal storage disorders. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t13415 |
| Works | 56 |

## Topic papers all

Showing 15 of 56.

- [Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis](https://scholariq.org/papers/exercise-induced-bcl2-regulated-autophagy-is-required-for-muscle-glucose/)
- [NAD+ metabolism in health and disease](https://scholariq.org/papers/nad-metabolism-in-health-and-disease/)
- [Nampt/PBEF/Visfatin Regulates Insulin Secretion in β Cells as a Systemic NAD Biosynthetic Enzyme](https://scholariq.org/papers/nampt-pbef-visfatin-regulates-insulin-secretion-in-cells-as-a-systemic-nad/)
- [Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans](https://scholariq.org/papers/discoveries-of-nicotinamide-riboside-as-a-nutrient-and-conserved-nrk-genes/)
- [Nicotinamide riboside is uniquely and orally bioavailable in mice and humans](https://scholariq.org/papers/nicotinamide-riboside-is-uniquely-and-orally-bioavailable-in-mice-and-humans/)
- [Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD<sup>+</sup> Precursor Vitamins in Human Nutrition](https://scholariq.org/papers/nicotinic-acid-nicotinamide-and-nicotinamide-riboside-a-molecular-evaluation-of/)
- [Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.](https://scholariq.org/papers/wortmannin-a-potent-and-selective-inhibitor-of-phosphatidylinositol-3-kinase/)
- [Molecular mechanisms of ATP secretion during immunogenic cell death](https://scholariq.org/papers/molecular-mechanisms-of-atp-secretion-during-immunogenic-cell-death/)
- [CD38-Mediated Immunosuppression as a Mechanism of Tumor Cell Escape from PD-1/PD-L1 Blockade](https://scholariq.org/papers/cd38-mediated-immunosuppression-as-a-mechanism-of-tumor-cell-escape-from-pd-1-pd/)
- [Small molecule regulators of autophagy identified by an image-based high-throughput screen](https://scholariq.org/papers/small-molecule-regulators-of-autophagy-identified-by-an-image-based-high/)
- [Cyclic ADP-Ribose in Insulin Secretion from Pancreatic βCells](https://scholariq.org/papers/cyclic-adp-ribose-in-insulin-secretion-from-pancreatic-cells/)
- [Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages](https://scholariq.org/papers/senescent-cells-promote-tissue-nad-decline-during-ageing-via-the-activation-of/)
- [IP <sub>3</sub> Receptor Types 2 and 3 Mediate Exocrine Secretion Underlying Energy Metabolism](https://scholariq.org/papers/ip-sub-3-sub-receptor-types-2-and-3-mediate-exocrine-secretion-underlying-energy/)
- [A conserved domain is present in different families of vesicular fusion proteins: A new superfamily](https://scholariq.org/papers/a-conserved-domain-is-present-in-different-families-of-vesicular-fusion-proteins/)
- [Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP.](https://scholariq.org/papers/synthesis-and-hydrolysis-of-cyclic-adp-ribose-by-human-leukocyte-antigen-cd38/)

## Topic primary papers

- [Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans](https://scholariq.org/papers/discoveries-of-nicotinamide-riboside-as-a-nutrient-and-conserved-nrk-genes/)
- [Nicotinamide riboside is uniquely and orally bioavailable in mice and humans](https://scholariq.org/papers/nicotinamide-riboside-is-uniquely-and-orally-bioavailable-in-mice-and-humans/)
- [Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD<sup>+</sup> Precursor Vitamins in Human Nutrition](https://scholariq.org/papers/nicotinic-acid-nicotinamide-and-nicotinamide-riboside-a-molecular-evaluation-of/)
- [CD38-Mediated Immunosuppression as a Mechanism of Tumor Cell Escape from PD-1/PD-L1 Blockade](https://scholariq.org/papers/cd38-mediated-immunosuppression-as-a-mechanism-of-tumor-cell-escape-from-pd-1-pd/)
- [Cyclic ADP-Ribose in Insulin Secretion from Pancreatic βCells](https://scholariq.org/papers/cyclic-adp-ribose-in-insulin-secretion-from-pancreatic-cells/)
- [Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages](https://scholariq.org/papers/senescent-cells-promote-tissue-nad-decline-during-ageing-via-the-activation-of/)
- [Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP.](https://scholariq.org/papers/synthesis-and-hydrolysis-of-cyclic-adp-ribose-by-human-leukocyte-antigen-cd38/)
- [The CD38/NAD/SIRTUIN1/EZH2 Axis Mitigates Cytotoxic CD8 T Cell Function and Identifies Patients with SLE Prone to Infections](https://scholariq.org/papers/the-cd38-nad-sirtuin1-ezh2-axis-mitigates-cytotoxic-cd8-t-cell-function-and/)
- [CD38 reduces mitochondrial fitness and cytotoxic T cell response against viral infection in lupus patients by suppressing mitophagy](https://scholariq.org/papers/cd38-reduces-mitochondrial-fitness-and-cytotoxic-t-cell-response-against-viral/)
- [CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice](https://scholariq.org/papers/cd38-deficiency-alleviates-ang-ii-induced-vascular-remodeling-by-inhibiting/)
- [The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease](https://scholariq.org/papers/the-role-of-ryanodine-receptor-type-3-in-a-mouse-model-of-alzheimer-disease/)
- [A Mathematical Model of Lysosomal Ion Homeostasis Points to Differential Effects of Cl− Transport in Ca2+ Dynamics](https://scholariq.org/papers/a-mathematical-model-of-lysosomal-ion-homeostasis-points-to-differential-effects/)
- [Mucolipidosis IV: Fetal and Placental Pathology](https://scholariq.org/papers/mucolipidosis-iv-fetal-and-placental-pathology/)
- [Effects of nicotinamide riboside on NAD+ levels, cognition, and symptom recovery in long-COVID: a randomized controlled trial](https://scholariq.org/papers/effects-of-nicotinamide-riboside-on-nad-levels-cognition-and-symptom-recovery-in/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.